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Roles of DIO family members and thyroid hormone in articular cartilage

Research Project

Project/Area Number 26670654
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAGAMI Ryota  東京大学, 医学部附属病院, 登録診療員 (00722191)

Co-Investigator(Kenkyū-buntansha) MORIZAKI Yutaka  東京大学, 医学部附属病院, 講師 (30508099)
TANIGUCHI Yuki  東京大学, 医学部附属病院, 助教 (80722165)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords整形外科学 / 軟骨代謝学
Outline of Final Research Achievements

We analyzed expression patterns of DIO1, DIO2, DIO3, and thyroid hormone receptors in articular cartilage. In primary culture of articular chondrocytes, thyroid hormone promoted cell proliferation, and suppressed dedifferentiation. However, overexpression of DIO did not lead to similar results.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Remarks (1 results)

  • [Journal Article] Impingement of the Mobile Bearing on the Lateral Wall of the Tibial Tray in Unicompartmental Knee Arthroplasty.2016

    • Author(s)
      Inui H, Taketomi S, Yamagami R, Sanada T, Shirakawa N, Tanaka S.
    • Journal Title

      J Arthroplasty

      Volume: 未定 Issue: 7 Pages: 1459-1464

    • DOI

      10.1016/j.arth.2015.12.047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myositis ossificans after navigated knee surgery: A report of two cases and literature review2016

    • Author(s)
      Yamagami R, Taketomi S, Inui H, Sanada T, Nakagawa T, Tanaka S
    • Journal Title

      Knee

      Volume: 23 Issue: 3 Pages: 561

    • DOI

      10.1016/j.knee.2015.11.023

    • URL

      https://pure.teikyo.jp/en/publications/bbe38297-d8a0-4f28-a009-4de36fd42ff1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secure fixation of femoral bone plug with a suspensory button in anatomical anterior cruciate ligament reconstruction with bone-patellar tendon-bone graft2016

    • Author(s)
      Taketomi S, Inui H, Nakamura K, Yamagami R, Tahara K, Sanada T, Masuda H, Tanaka S, Nakagawa T
    • Journal Title

      Joints

      Volume: 3 Issue: 3 Pages: 102

    • DOI

      10.11138/jts/2015.3.3.102

    • URL

      https://localhost/en/publications/8a24a960-fa88-4e59-9d7a-cffe8e080d8e

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Twice cutting method reduces tibial cutting error in unicompartmental knee arthroplasty2016

    • Author(s)
      Inui H, Taketomi S, Yamagami R, Sanada T, Tanaka S
    • Journal Title

      Knee

      Volume: 23 Issue: 1 Pages: 173-176

    • DOI

      10.1016/j.knee.2014.11.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.2015

    • Author(s)
      Sugita S, Taketomi S, Saito T, et al.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 112 Issue: 10 Pages: 3080-5

    • DOI

      10.1073/pnas.1419699112

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Remnant-preserving anterior cruciate ligament reconstruction using a three-dimensional fluoroscopic navigation system2014

    • Author(s)
      Taketomi S, et al.
    • Journal Title

      Knee Surg Relat Res.

      Volume: 26 Issue: 3 Pages: 168

    • DOI

      10.5792/ksrr.2014.26.3.168

    • URL

      https://pure.teikyo.jp/en/publications/40ced5bd-4e5b-4e59-a379-e88faf8e60b9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eccentric femoral tunnel widening in anatomic anterior cruciate ligament reconstruction.2014

    • Author(s)
      Taketomi S, Yamagami R, et al.
    • Journal Title

      Arthroscopy

      Volume: 30 Issue: 6 Pages: 701-9

    • DOI

      10.1016/j.arthro.2014.02.016

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.2014

    • Author(s)
      Nakajima M, Takahashi A, Tsuji T, Furukawa K-I et al.
    • Journal Title

      Nature Genetics

      Volume: 46 Issue: 9 Pages: 1012-1016

    • DOI

      10.1038/ng.3045

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Remarks] 東京大学医学部整形外科

    • URL

      http://www.u-tokyo-ortho.jp/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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