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Analysis of the high ability of urodele amphibians to regenerate articular cartilage and application of the underlying mechanism to regeneration of mammalian cartilage

Research Project

Project/Area Number 26670655
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Chikuda Hirotaka  東京大学, 医学部附属病院, 准教授 (30345219)

Co-Investigator(Kenkyū-buntansha) YAMAGAMI Ryota  東京大学, 医学部附属病院, 登録診療員 (00722191)
TAKETOMI Shuji  東京大学, 医学部附属病院, 講師 (70570018)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords変形性関節症 / 再生医療 / 関節軟骨 / 有尾両生類
Outline of Final Research Achievements

Axolotl, a species of urodele amphibians, has very high ability to regenerate its tissues. In contrast to mammals, including humans, whose articular cartilage regenerates very poorly, axolotl is known to be able to completely regenerate defects extending the full-depth of the articular cartilage. In this study, we attempted to identify the mechanisms underlying the regenerative capacity of axolotls.
We resected full-thickness knee articular cartilage from axolotl. At 4 weeks after surgery, we harvested the cartilage and extracted its RNA. Then we analyzed gene expression profiles by next-generation sequencing. This analysis suggested that both genes previously known to be important for regeneration of whole limb and genes specific to articular cartilage regeneration are involved in the regeneration of axolotl articular cartilage.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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