In vitro bone generation trial using multi-walled carbon nanotube blocks

• Project/Area Number: 26670658
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Shinshu University
• Principal Investigator: TANAKA Manabu 信州大学, 医学部附属病院, 医員 (30723069)
• Co-Investigator(Kenkyū-buntansha): SATO Yoshinori 東北大学, 環境科学研究科, 准教授 (30374995) ; HANIU Hisao 信州大学, 学術研究院医学系, 准教授 (30252050)
• Co-Investigator(Renkei-kenkyūsha): SAITO Naoto 信州大学, 学術研究院保健学系, 教授 (80283258) ; AOKI Kaoru 信州大学, 医学部, 准教授 (30467170)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: カーボンナノチューブ / 再生医療 / 整形外科

Outline of Final Research Achievements

Multi-walled carbon nanotubes were formed in a shape suitable for bone regeneration (CNTp), and evaluated the possibility of applications in bone regeneration medicine. We couldn't produce bones in vitro but CNTp showed good cell proliferation, bone conduction, and excellent capacity to hold and release of the drug sustainably. It was suggested that CNTp can be applied to regenerative medicine using tissue engineering not only as a filler of the bone defect, but also as a scaffold material transplanted by culturing cells and as a carrier for controlled release of drugs.

Research Products

• [Presentation] 多孔質に成型した多層カーボンナノチューブブロック体の骨形成への影響 (2016)
  • Author(s): 田中学 齋藤直人 Mei Zhang 佐藤義倫 羽二生久夫 滝沢崇 野村博紀 小林伸輔 岡本正則 高梨誠司 青木薫 薄井雄企 加藤博之
  • Organizer: 第117回信州整形外科懇談会
  • Place of Presentation: 信州大学医学部
  • Year and Date: 2016-02-20
• [Presentation] Porous Multi-Walled Carbon Nanotube block (p-MWCNT block) の骨形成への影響 (2015)
  • Author(s): 田中学 齋藤直人 Mei Zhang 佐藤義倫 羽二生久夫 滝沢崇 野村博紀 小林伸輔 岡本正則 高梨誠司 青木薫 薄井雄企 加藤博之
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2015-10-22
• [Presentation] A capacity of porous multi-walled carbon nanotube blocks as scaffold of bone regeneration (2015)
  • Author(s): Tanaka M, Saito N, Zhang M, Sato Y, Haniu H, Takizawa T, Nomura H, Kobayashi S, Okamoto M, Takanashi S, Aoki K, Usui Y, Kato H.
  • Organizer: 12th Bone Biology Forum
  • Place of Presentation: クロスウェーブ幕張
  • Year and Date: 2015-08-03
  • Int'l Joint Research
• [Presentation] The effect of carbon nanotube blocks on bone regeneration (2015)
  • Author(s): Tanaka M, Saito N, Zhang M, Sato Y, Haniu H, Takizawa T, Nomura H, Kobayashi S, Okamoto M, Takanashi S, Aoki K, Usui Y, Kato H.
  • Organizer: Sixth Symposium on Carbon Nanomaterials Biology, Medicine & Toxicology
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-06-28
  • Int'l Joint Research
• [Presentation] Multi-Walled Carbon Nanotube (MWCNT) block の骨形成への影響 (2014)
  • Author(s): 田中学
  • Organizer: 第29回日本整形外科学会基礎学術集会
  • Place of Presentation: 城山観光ホテル（鹿児島）
  • Year and Date: 2014-10-09 – 2014-10-10