| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Osteoporosis is a serious disease among elderly people in developed countries, which can lead to bone fractures. In the elderly population, spine and hip fractures are chronic diseases characterized by an abnormal balance in the activities of osteoclasts and osteoblasts. PTH drug is highly effective in the treatment of osteoporosis, but its mechanism of action is largely unknown. Here we report the Mass Microscopy analysis of cortical bone from PTH treated mice. PTH treatment induces certain kind of lipid in cortical bone area and such lipid may contribute to the prophylaxis of PTH drug.
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