Mass microscopy imaging of bone
| Project/Area Number |
26670663
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
Maruyama Kenta 大阪大学, 免疫学フロンティア研究センター, 特任助教 (60724119)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨代謝 / 質量顕微鏡 / PTH / 骨粗鬆症 / ＰＴＨ / 骨形成 |
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| Outline of Final Research Achievements |
Osteoporosis is a serious disease among elderly people in developed countries, which can lead to bone fractures. In the elderly population, spine and hip fractures are chronic diseases characterized by an abnormal balance in the activities of osteoclasts and osteoblasts. PTH drug is highly effective in the treatment of osteoporosis, but its mechanism of action is largely unknown. Here we report the Mass Microscopy analysis of cortical bone from PTH treated mice. PTH treatment induces certain kind of lipid in cortical bone area and such lipid may contribute to the prophylaxis of PTH drug.
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Report
(3 results)
Research Products
(13 results)
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[Patent(Industrial Property Rights)] 組織損傷治療剤2016
Inventor(s)
丸山健太、ミカエルマルティ―ノエム、審良静男
Industrial Property Rights Holder
丸山健太、ミカエルマルティ―ノエム、審良静男
Industrial Property Rights Type
特許
Industrial Property Number
2016-036869
Filing Date
2016-03-16
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