New try of bone revival using embryonic stem cell introduced bone specific promoter and reporter gene
| Project/Area Number |
26670669
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Miyazaki |
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Principal Investigator |
Tomomi Ota 宮崎大学, 医学部, 医員 (80644096)
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| Co-Investigator(Kenkyū-buntansha) |
帖佐 悦男 宮崎大学, 医学部, 教授 (00236837)
関本 朝久 宮崎大学, 医学部, 講師 (60305000)
荒木 正健 熊本大学, 生命資源研究・支援センター, 准教授 (80271609)
荒木 喜美 熊本大学, 生命資源研究・支援センター, 教授 (90211705)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ES細胞 / 骨特異的プロモーター / トランスジーン / 骨分化特異的培養 / 骨再生 |
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| Outline of Final Research Achievements |
We manufacture TransGene who connected a reporter gene to the promoter who specifically emerges to osseous tissue, and this study is intended that I examine a culture condition for differentiation to multiply it to a bone using the mouse embryonic stem cell which I introduced it into specifically and effectively.And we examine the possibility of the application to the treatment such as bone graft or the bone fracture. It is a design to connect this study with development of the new bone regenerative medicine in the near future.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models2017
Author(s)
Syuji Kurogi, Tomohisa Sekimoto, Taro Funamoto, Tomomi Ohta, Shihoko Nakamura, Takuya Nagai, Mai Nakahara, Kumiko Yoshinobu, Kimi Araki, Masatake Araki, Etsuo Chosa
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Journal Title
Scientific Reports
Volume: 7
Pages: 40692-40692
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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