Activation mechanism of synovial cells: depression of p53-function by stretching
| Project/Area Number |
26670670
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 滑膜細胞 / 変形性関節炎 / グルコサミン / Cox-2 / 関節炎 / NFκB / p53 / 伸展ストレス / DNp73α / アポトーシス / 15d-PGJ2 |
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| Outline of Final Research Achievements |
Activation of synoviocytes that construct synovial tissue is a major pathological condition. Although glucosamine is usefull as a component of articular cartilage for regeneration of the cartilage, but it is unknown whether glucosamine affects the activation of synoviocytes.
I examined the effect of glucosamine on stretch-dependent activation of synoviocytes using a cell stretch-loading system. The pretreatment of synoviocytes with glucosamine suppressed stretch-dependent Cox-2 expression, which is a typical hallmark of synoviocytes activation. In addition, glucosamine strongly suppressed an inflammatory reagent-dependent Cox-2 expression. These results suggest that glucosamine has an ability to inhibit the synoviocyte activation.
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Report
(3 results)
Research Products
(3 results)
