Effect of hydrogen sulfide on calcium homeostasis.
| Project/Area Number |
26670673
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ガスメディエーター / ビタミンD / 硫化水素 / 骨カルシウム代謝 / 骨・軟骨代謝 |
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| Outline of Final Research Achievements |
Hydrogen sulfide has been recognized as a gaseous mediator with a variety of physiological functions. However, its role in the control of skeletal function is unknown. Hydrogen sulfide can be physiologically generated by enzymes, cystathionine beta-synthase (CBS). To define the physiological function of hydrogen sulfide in the skeletal tissue, we performed functional analysis of bone metabolism in CBS knockout mice. The knockout mice showed disturbance of calcium metabolism. These results suggest that hydrogen sulfide is essential for calcium homeostasis.
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Report
(3 results)
Research Products
(6 results)
