Elucidating mechanisms of altered bone matrix mineralization
| Project/Area Number |
26670674
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
MATSUO Koichi 慶應義塾大学, 医学部, 教授 (40229422)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨基質 / ミネラリゼーション / 石灰化 / 骨芽細胞 / 基質小胞 / 骨代謝 |
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| Outline of Final Research Achievements |
Bone matrix mineralization (calcification) proceeds through organized deposition of calcium hydroxyapatite crystals on collagen fibers. Both hyper- and hypomineralzation reduce bone mechanical properties. Mice lacking tyrosine kinase receptor EphA showed hypermineralization likely due to altered growth of mineralizing nodules.
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Report
(3 results)
Research Products
(11 results)
