Molecular mechanisms for loss of contact inhibition in the cell motility of sarcoma and cancer invasion
Project/Area Number |
26670677
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
Principal Investigator |
TAKAHASHI Katsuhito 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (40211338)
|
Co-Investigator(Kenkyū-buntansha) |
YAMAMURA Hisako 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 研究員 (50342994)
|
Co-Investigator(Renkei-kenkyūsha) |
TOGUCHIDA Jyunya 京都大学, 生医科学研究所, 教授 (40273502)
|
Project Period (FY) |
2014-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | かルポニン / 上皮間葉系転換 / カルポニン |
Outline of Final Research Achievements |
Cnn2 expression was examined in human breast cancer tissue microarrays and surgically resected tissues from human desmoplastic small round cell tumors (DSRCT) and malignant mesothelioma. Cnn2 was expressed in 30% of the 50 tissues samples of breast cancer, predominantly in the triple negative and high grade tumors. It was also highly expressed in all DSRCT and malignant mesothelioma tissues examined. 1D-Collision Assay system was established in mouse vascular smooth muscle and human clear cell sarcoma cells using the 1D motility assay chips and microscopic time lapse analyses. A 188bp-region containing CArG box upstream from transcrition start site in the mouse Cnn2 gene was identified as an essential promoter region for Cnn2 expression. The 239bp-region upstream from the transcription start site containig the above 188bp-region was most highy conserved in the human Cnn2 gene.
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Report
(2 results)
Research Products
(6 results)
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[Presentation] Clinical evaluation and treatment of leiomyosarcoma.2014
Author(s)
K.Takahashi, H. Yamamura, Y. Koike, H. Narahara, Y. Ooyama, S. Toyooka, R. Hatae, Y. Ono, J. Yashima, S. Teraoka
Organizer
The Japan-United States International Workshop for Sarcoma Research and Therapy
Place of Presentation
Honolulu
Year and Date
2014-12-04 – 2014-12-05
Related Report
Invited
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[Presentation] Pazopanib for metastatic soft tissue sarcoma (STS) with or without denosumab.2014
Author(s)
H. Narahara, K. Yasuda, K. Morita, N. Dan, R. Takeda, Y. Takeda, K. Yanagawa, J. Fukushima, H. Matsumoto, K. Matsunaga, S. Ueda, Y. Yasunaga, Y. Inui, S. Kawata, H. Yamamura, K. Takahashi.
Organizer
The 39th Annual Meeting of The European Society of Medical Oncology (ESMO)
Place of Presentation
Madrid
Year and Date
2014-09-26 – 2014-09-30
Related Report
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[Presentation] Systemic chemotherapy of pazopanib for advanced soft tissue sarcoma (STS) with or without denosumab.2014
Author(s)
H. Narahatra, K. Yasuda, K. Morita, N. Dan, R. Takeda, Y. Takeda, K. Yanagawa, J. Fukushima, H. Matsumoto, K. Matsunaga, S. Ueda, Y. Yasunaga, Y. Inui, S. Kawata, H. Yamamura, K. Takahashi.
Organizer
The 12th Annual Meeting of Japanese Society of Medical Oncology
Place of Presentation
Fukuoka
Year and Date
2014-07-17
Related Report