The role of the descending inhibitory system in endogenous analgesia
Project/Area Number |
26670678
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology
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Research Institution | Fukushima Medical University (2015-2016) Gunma University (2014) |
Principal Investigator |
Obata Hideaki 福島県立医科大学, 医学部, 教授 (20302482)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | ノルアドレナリン / 内因性鎮痛 / 下行性抑制系 / 神経障害性疼痛 / 内因性鎮痛系 / セロトニン |
Outline of Final Research Achievements |
We examined the change in endogenous analgesia (NSIA) over time after right L5 spinal nerve ligation (SNL) in rats. NSIA was attenuated 5 and 6 w after SNL accompanied with dysfunction of the descending noradrenergic inhibition. These were recovered by five daily injections of amitriptyline (10 mg/kg/day). These data suggest that endogenous analgesia in neuropathic pain states is strongly decreased from a certain time after nerve injury, and amitriptyline reverses the attenuation of endogenous analgesia. In the clinical study, we examined the effect of pregabalin in endogenous analgesia using CPM. CPM were measured before and after pregabalin or placebo administration. Fifty-nine healthy subjects were randomly assigned to either a pregabalin group or a placebo group. The correlation between initial CPM and the change in CPM was significantly strong in pregabalin group compared to placebo group. Pregabalin could be more effective in subjects with the lower endogenous analgesia.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] In vivo and in vitro evaluation of novel μ-opioid receptor agonist compounds2015
Author(s)
Nikaido Y, Kurosawa A, Saikawa H, Kuroiwa S, Suzuki C, Kuwabara N, Hoshino H, Obata H, Saito S, Saito T, Osada H, Kobayashi I, Sezutsu H, Takeda S
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Journal Title
Eur J Pharmacol
Volume: 767
Pages: 193-200
DOI
Related Report
Peer Reviewed
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