| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
We examined the change in endogenous analgesia (NSIA) over time after right L5 spinal nerve ligation (SNL) in rats. NSIA was attenuated 5 and 6 w after SNL accompanied with dysfunction of the descending noradrenergic inhibition. These were recovered by five daily injections of amitriptyline (10 mg/kg/day). These data suggest that endogenous analgesia in neuropathic pain states is strongly decreased from a certain time after nerve injury, and amitriptyline reverses the attenuation of endogenous analgesia.
In the clinical study, we examined the effect of pregabalin in endogenous analgesia using CPM. CPM were measured before and after pregabalin or placebo administration. Fifty-nine healthy subjects were randomly assigned to either a pregabalin group or a placebo group. The correlation between initial CPM and the change in CPM was significantly strong in pregabalin group compared to placebo group. Pregabalin could be more effective in subjects with the lower endogenous analgesia.
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