| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
First of all, on the basis of the parameters of the animal experiments, mean arterial pressure, diastolic arterial pressure, pre-ejection period, and ejection time were measured to calculate the left ventricular-arterial coupling (Ees/Ea) using the daily bed side monitors of electrocardiogram, the arterial pressure waveform and phonocardiogram. Then, stroke volume was measured with transthoracic echocardiogram to estimate the left ventricular end-diastolic volume (Ved) with the four parameters under the hypothesis that unstressed volume of the left ventricle should be zero ml. Ved is an important indicator of excess or deficiency of the blood volume. Since the results showed the large variation in the calculated values, an original tool was developed, which was a personal computer with a card type A/D converter and original applications, to determine Ees/Ea as the mean values during 10 seconds with continuous measurements of the four parameters beat-by-beat at the bed side.
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