The verification for the lipid hypothesis of the inhalational anesthetics

Research Project

Project/Area Number	26670683
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	University of Fukui
Principal Investigator	Mita Kenichiro 福井大学, 学術研究院医学系部門, 特別研究員 (30529342)
Co-Investigator(Renkei-kenkyūsha)	OIKI Shigetoshi 福井大学, 学術研究院医学系部門, 教授 (10185176)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	イオンチャネル / 吸入麻酔薬 / 脂質仮説 / 側方圧 / 麻酔薬
Outline of Final Research Achievements	The mechanisms of the anesthetic drugs to human body have not been elucidated for the long time. Until now, many hypotheses have been advocated. One popular hypothesis is the lipid theory. No one could confirm its validity. We challenged to test the assumption that the anesthetics exert their actions to ion channels mediated by pressures laterally. We decided to use the tension force of the lipid bilayer membrane as a substitute for lateral pressure. We tried to measure the tension force by several ways, but unfortunately we could not measure it and observe the currents of the ion channels.