The research to examine the potential of anesthetic agents to attenuate the memory

• Project/Area Number: 26670691
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: GOTO Takahisa 横浜市立大学, 医学(系)研究科(研究院), 教授 (00256075)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 行動実験 / 麻酔薬 / 恐怖記憶 / ミダゾラム

Outline of Final Research Achievements

Previous reports showed the potential of midazolam to attenuate the flash back caused by PTSD. Nobody knows if this effect is mediated by the attenuation of autonomic nerve response or the erasure of the adverse memory itself. This study aims to discriminate these two factors. We revealed that midazolam does not the erase memory itself but attenuates the autonomic nerve response.