Does the bladder C fiber inhibition improve nocturnal polyuria in the metabolic syndrome era?

• Project/Area Number: 26670698
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: University of Fukui
• Principal Investigator: OKADA MASAHIRO 福井大学, 医学部附属病院, 助教 (40572441)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA OSAMU 福井大学, 医学部, 教授 (90242552) ; AOKI YOSHITAKA 福井大学, 医学部附属病院, 講師 (30273006) ; YOKOI SATOSHI 福井大学, 医学部附属病院, 助教 (90722546) ; SEKI MASAYA 福井大学, 医学部附属病院, 医員 (70572444)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 夜間頻尿 / 多尿 / 尿産生リズム / 腎交感神経 / 心不全

Outline of Final Research Achievements

Antimuscarinics have the potential to decrease nocturnal urine volume via suppression of bladder afferent C-fibers. Can other antimuscarinics and α-adrenergic blocker decrease urine production?
Intravenous α blocker naftopidil decreased the urine production in rats with diuresis. This effect was found to depend on its inhibitory influences on C-fibers. We examined influences of the sympathetic nervous hyperactivity on urine production and micturition reflex in Dahl salt-sensitive rats fed with high salt diet. These rats revealed hypertension and increase in urine production during inactive periods of the day. Urine-producing rhythm collapsed when a heart failure model was made using an anticancer agent adriamycin with heart toxicity. An antidiuretic effect was clinically seen in short-acting anticholinergics administered before sleeping when sub-analyzed the data of clinical trial. On the other hand, an antidiuretic effect was not found in long-acting anticholinergics.

Research Products

• [Journal Article] Once-daily oxybutynin patch improves nocturia and sleep quality in Japanese patients with overactive bladder: Post-hoc analysis of a phaseIII randomized clinical trial (2015)
  • Author(s): Yokoyama O, Yamaguchi A, Yoshida M, Yamanishi T, Ishizuka O, Seki N, Takahashi S, Yamaguchi O, Higo N, Minami H, Masegi Y.
  • Journal Title: INTERNATIONAL JOURNAL OF UROLOGY Volume: 22 Issue: 7 Pages: 684-688
  • DOI: 10.1111/iju.12755
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Underlying mechanisms of urine storage dysfunction in rats with salt-loading hypertension (2015)
  • Author(s): Kurokawa T, Zha X, Ito H, Aoki Y, Akino H, Kobayashi M, Yokoyama O
  • Journal Title: Life Sci Volume: 141 Pages: 8-12
  • DOI: 10.1016/j.lfs.2015.09.010
  • Peer Reviewed
• [Presentation] Natural History of Nocturia Among Japanese Men and Women During the 5-Year Period from 2003 to 2007. (2014)
  • Author(s): Y.Aoki, S.Yokoi, M.Okada, Y.Matsuta, C.Matsumoto, Y.Kusaka, O.Yokoyama
  • Organizer: ICS2014
  • Place of Presentation: リオデジャネイロ（ブラジル）
  • Year and Date: 2014-10-22
• [Presentation] 夜間頻尿の変動パターンからみた、経過観察という治療方針の可能性－住民健康診査受診者における縦断解析結果－ (2014)
  • Author(s): 青木 芳隆, 松本 智恵子, 岡田 昌裕, 松田 陽介, 伊藤 秀明, 大山 伸幸, 秋野 裕信, 日下 幸則, 横山 修
  • Organizer: 第21回日本排尿機能学会
  • Place of Presentation: 岡山市（岡山コンベンションセンター）
  • Year and Date: 2014-09-18
• [Presentation] 住民健診受診者を対象とした縦断的解析からわかった夜間頻尿の変動について (2014)
  • Author(s): 青木 芳隆, 岡田 昌裕, 松田 陽介, 松本 智恵子, 日下 幸則, 横山 修
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸市（神戸国際会議場、他）
  • Year and Date: 2014-04-27
• [Presentation] 慢性疾患にて一般医家通院中の60,034名におけるlower urinary tract symptoms(LUTS) 治療率と生活習慣病の相関に関する検討 (2014)
  • Author(s): 関 雅也, 山内 寛喜, 岡田 昌裕, 青木 芳隆, 横山 修
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸市（神戸国際会議場、他）
  • Year and Date: 2014-04-24
• [Remarks] 福井大学研究者総覧
  • URL: http://t-profile.ad.u-fukui.ac.jp/search/index.html
• [Remarks] 福井大学医学部研究活動一覧
  • URL: http://www.med.u-fukui.ac.jp/home/ufms/file/kenkyu/welcome.html