| Project/Area Number |
26670698
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Fukui |
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Principal Investigator |
OKADA MASAHIRO 福井大学, 医学部附属病院, 助教 (40572441)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA OSAMU 福井大学, 医学部, 教授 (90242552)
AOKI YOSHITAKA 福井大学, 医学部附属病院, 講師 (30273006)
YOKOI SATOSHI 福井大学, 医学部附属病院, 助教 (90722546)
SEKI MASAYA 福井大学, 医学部附属病院, 医員 (70572444)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 夜間頻尿 / 多尿 / 尿産生リズム / 腎交感神経 / 心不全 |
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| Outline of Final Research Achievements |
Antimuscarinics have the potential to decrease nocturnal urine volume via suppression of bladder afferent C-fibers. Can other antimuscarinics and α-adrenergic blocker decrease urine production?
Intravenous α blocker naftopidil decreased the urine production in rats with diuresis. This effect was found to depend on its inhibitory influences on C-fibers. We examined influences of the sympathetic nervous hyperactivity on urine production and micturition reflex in Dahl salt-sensitive rats fed with high salt diet. These rats revealed hypertension and increase in urine production during inactive periods of the day. Urine-producing rhythm collapsed when a heart failure model was made using an anticancer agent adriamycin with heart toxicity. An antidiuretic effect was clinically seen in short-acting anticholinergics administered before sleeping when sub-analyzed the data of clinical trial. On the other hand, an antidiuretic effect was not found in long-acting anticholinergics.
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