| Project/Area Number |
26670706
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Takahara Siro 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70179547)
Isaka Yoshitaka 大阪大学, 医学(系)研究科(研究院), 教授 (00379166)
Li Xiaokang 国立成育医療センター(研究所), 移殖、外科研究部, 室長 (60321890)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | CD28-Supergonist / 非特異的免疫抑制細胞 / Ｔｒｅｇバンク / ドナー特異的な免疫寛容 / Tregバンク / CD34+幹細胞 / ﾄﾞﾅｰ特異的な免疫寛容 / 腎移植 / 免疫寛容 / CD28SA |
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| Outline of Final Research Achievements |
The purpose of this study is the permanent survival of allografts by means of the establishment of novel strategy of induction of postoperatively sensitized immune tolerance. We tested the effect of combined therapy of ①adoptive transfer of Treg cells proliferated in in vitro culture system, so called “Treg bank” and ②the gene transfection of MF-1, which protect the kidney tissue from the all sorts of injuries after engraftment.
We have obtained the following results so far. The first, "the establishment of MF-1 gene transfection to the transplanted kidney tissue, which establish the protective gene transfer therapy of the allografts. Second, the improvement of immune tolerance induction rate by adoptive transfer of Treg supplied by Treg bank in which Treg are proliferated in in vitro system. Those results may realize the establishment of new immune tolerance method and the renal transplant without using immunosuppressive agents may be feasible.
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