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The permanent survival of allografts by tolerance induction mediated by the combined therapy of adoptive transfer of Treg cells and the MF-1-gene transfection

Research Project

Project/Area Number 26670706
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka Medical College

Principal Investigator

Azuma Haruhito  大阪医科大学, 医学部, 教授 (40231914)

Co-Investigator(Kenkyū-buntansha) Takahara Siro  大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70179547)
Isaka Yoshitaka  大阪大学, 医学(系)研究科(研究院), 教授 (00379166)
Li Xiaokang  国立成育医療センター(研究所), 移殖、外科研究部, 室長 (60321890)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsCD28-Supergonist / 非特異的免疫抑制細胞 / Tregバンク / ドナー特異的な免疫寛容 / Tregバンク / CD34+幹細胞 / ドナー特異的な免疫寛容 / 腎移植 / 免疫寛容 / CD28SA
Outline of Final Research Achievements

The purpose of this study is the permanent survival of allografts by means of the establishment of novel strategy of induction of postoperatively sensitized immune tolerance. We tested the effect of combined therapy of ①adoptive transfer of Treg cells proliferated in in vitro culture system, so called “Treg bank” and ②the gene transfection of MF-1, which protect the kidney tissue from the all sorts of injuries after engraftment.
We have obtained the following results so far. The first, "the establishment of MF-1 gene transfection to the transplanted kidney tissue, which establish the protective gene transfer therapy of the allografts. Second, the improvement of immune tolerance induction rate by adoptive transfer of Treg supplied by Treg bank in which Treg are proliferated in in vitro system. Those results may realize the establishment of new immune tolerance method and the renal transplant without using immunosuppressive agents may be feasible.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Intravesical administration of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft.2015

    • Author(s)
      Inamoto T, Taniguchi K, Takahara K, Iwatsuki A, Takai T, Komura K, Yoshikawa Y, Uchimoto T, Saito K, Tanda N, Kouno J, Minami K, Uehara H, Hirano H, Nomi H, Kiyama S, Akao Y, Azuma H.
    • Journal Title

      Oncotarget.

      Volume: 6 Pages: 21628-35

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Anti-Proliferative Effect of Boron Neutron Capture Therapy in Prostate Cancer Xenograft Model2015

    • Author(s)
      Takahara K, Inamoto T, Minami K, Yoshikawa Y, Takai T, Ibuki N, Hirano H, Nomi H, Kawabata S, Kiyama S, Miyatake S, Kuroiwa T, Suzuki M, Kirihata M, Azuma H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: 136981-2

    • DOI

      10.1371/journal.pone.0136981

    • NAID

      120005763435

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel bladder preservation therapy with Osaka Medical College regimen.2015

    • Author(s)
      Azuma H, Inamoto T, Takahara K, Nomi H, Hirano H, Ibuki N, Uehara H, Komura K, Minami K, Uchimoto T, Saito K, Takai T, Tanda N, Yamamoto K, Narumi Y, Kiyama S.
    • Journal Title

      J Urol.

      Volume: 193 Issue: 2 Pages: 443-450

    • DOI

      10.1016/j.juro.2014.08.094

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial.2015

    • Author(s)
      Komura K, Inamoto T, Takai T, Uchimoto T, Saito K, Tanda N, Minami K, Oide R, Uehara H, Takahara K, Hirano H, Nomi H, Kiyama S, Watsuji T, Azuma H.
    • Journal Title

      BJU Int.

      Volume: 115 Issue: 4 Pages: 645-652

    • DOI

      10.1111/bju.12831

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Could Transurethral Resection of the Prostate Using the TURis System Take Over Conventional Monopolar Transurethral Resection of the Prostate? A Randomized Controlled Trial and Midterm Results2014

    • Author(s)
      Kazumasa Komura, Teruo Inamoto, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Hirofumi Uehara, Kiyoshi Takahara, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Toshikazu Watsuji, Haruhito Azuma
    • Journal Title

      Urology

      Volume: 84 Issue: 2 Pages: 405-11

    • DOI

      10.1016/j.urology.2014.04.025

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The novel bladder preservation therapy BOAI-CDDP-radiation (OMC-regimen): a new treatment option for invasive bladder cancer patients with lymph node metastasis.2014

    • Author(s)
      Azuma H, Inamoto T, Takahara K, Nomi H, Hirano H, Ibuki N, Uehara H, Komura K, Minami K, Uchimoto T, Saito K, Takai T, Tanda N, Yamamoto K, Narumi Y, Kiyama S.
    • Journal Title

      Int J Oncol.

      Volume: 44 Issue: 6 Pages: 1895-1903

    • DOI

      10.3892/ijo.2014.2378

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] SUCCESSFULLY RESULTED IN A SHARP INCREASE OF THE NUMBER OF RENAL TRANSPLANTATION; STRATEGY OF OUR CENTER2015

    • Author(s)
      Hayahito Nomi, Ryoichi Maenosono, Matsunaga Kazuhisa, Takahara Kiyoshi, Inamoto Teruo, Satoshi Kiyama, Haruhito Azuma
    • Organizer
      Congress of the Asian Society of Transplantation
    • Place of Presentation
      SantecSingaporeConvention and ExhibitionCenter(Singapore)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinom2015

    • Author(s)
      Shigeru Sakano, Tomoaki Takai, Kazumasa Komura, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Kazuhiro Nagao, Ryo Inoue, Kiyoshi Takahara, Hideyasu Matsuyama, Haruhito Azuma
    • Organizer
      American Urological Association's 2015 Annual Meeting
    • Place of Presentation
      NewOrleansMorialConventionCenter(NewOrleans USA)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アロ活性化マクロファージによるアロ移植細胞の拒絶機構に関する検討2014

    • Author(s)
      能見勇人 平野 一、前之園良一、西本優大、松永知久、吉川勇希、齋藤賢吉、内本泰三、南 幸一郎、木山 賢、東 治人
    • Organizer
      第50回日本移植学会総会
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 移植後リンパ増殖性疾患(PTLD)の治療後に発症した薬剤性間質性肺炎の一例2014

    • Author(s)
      平野 一能見勇人、齋藤賢吉、前之園良一、松永知久、反田 直希、内本泰三、髙井朋聡、南 幸一郎、高原 健、稲元輝生、木山 賢、東 治人
    • Organizer
      第50回日本移植学会総会
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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