The permanent survival of allografts by tolerance induction mediated by the combined therapy of adoptive transfer of Treg cells and the MF-1-gene transfection
Project/Area Number |
26670706
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Osaka Medical College |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
Takahara Siro 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70179547)
Isaka Yoshitaka 大阪大学, 医学(系)研究科(研究院), 教授 (00379166)
Li Xiaokang 国立成育医療センター(研究所), 移殖、外科研究部, 室長 (60321890)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | CD28-Supergonist / 非特異的免疫抑制細胞 / Tregバンク / ドナー特異的な免疫寛容 / Tregバンク / CD34+幹細胞 / ドナー特異的な免疫寛容 / 腎移植 / 免疫寛容 / CD28SA |
Outline of Final Research Achievements |
The purpose of this study is the permanent survival of allografts by means of the establishment of novel strategy of induction of postoperatively sensitized immune tolerance. We tested the effect of combined therapy of ①adoptive transfer of Treg cells proliferated in in vitro culture system, so called “Treg bank” and ②the gene transfection of MF-1, which protect the kidney tissue from the all sorts of injuries after engraftment. We have obtained the following results so far. The first, "the establishment of MF-1 gene transfection to the transplanted kidney tissue, which establish the protective gene transfer therapy of the allografts. Second, the improvement of immune tolerance induction rate by adoptive transfer of Treg supplied by Treg bank in which Treg are proliferated in in vitro system. Those results may realize the establishment of new immune tolerance method and the renal transplant without using immunosuppressive agents may be feasible.
|
Report
(3 results)
Research Products
(10 results)
-
[Journal Article] Intravesical administration of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft.2015
Author(s)
Inamoto T, Taniguchi K, Takahara K, Iwatsuki A, Takai T, Komura K, Yoshikawa Y, Uchimoto T, Saito K, Tanda N, Kouno J, Minami K, Uehara H, Hirano H, Nomi H, Kiyama S, Akao Y, Azuma H.
-
Journal Title
Oncotarget.
Volume: 6
Pages: 21628-35
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] The Anti-Proliferative Effect of Boron Neutron Capture Therapy in Prostate Cancer Xenograft Model2015
Author(s)
Takahara K, Inamoto T, Minami K, Yoshikawa Y, Takai T, Ibuki N, Hirano H, Nomi H, Kawabata S, Kiyama S, Miyatake S, Kuroiwa T, Suzuki M, Kirihata M, Azuma H.
-
Journal Title
PLoS One
Volume: 10
Issue: 9
Pages: 136981-2
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Novel bladder preservation therapy with Osaka Medical College regimen.2015
Author(s)
Azuma H, Inamoto T, Takahara K, Nomi H, Hirano H, Ibuki N, Uehara H, Komura K, Minami K, Uchimoto T, Saito K, Takai T, Tanda N, Yamamoto K, Narumi Y, Kiyama S.
-
Journal Title
J Urol.
Volume: 193
Issue: 2
Pages: 443-450
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial.2015
Author(s)
Komura K, Inamoto T, Takai T, Uchimoto T, Saito K, Tanda N, Minami K, Oide R, Uehara H, Takahara K, Hirano H, Nomi H, Kiyama S, Watsuji T, Azuma H.
-
Journal Title
BJU Int.
Volume: 115
Issue: 4
Pages: 645-652
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Could Transurethral Resection of the Prostate Using the TURis System Take Over Conventional Monopolar Transurethral Resection of the Prostate? A Randomized Controlled Trial and Midterm Results2014
Author(s)
Kazumasa Komura, Teruo Inamoto, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Hirofumi Uehara, Kiyoshi Takahara, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Toshikazu Watsuji, Haruhito Azuma
-
Journal Title
Urology
Volume: 84
Issue: 2
Pages: 405-11
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] The novel bladder preservation therapy BOAI-CDDP-radiation (OMC-regimen): a new treatment option for invasive bladder cancer patients with lymph node metastasis.2014
Author(s)
Azuma H, Inamoto T, Takahara K, Nomi H, Hirano H, Ibuki N, Uehara H, Komura K, Minami K, Uchimoto T, Saito K, Takai T, Tanda N, Yamamoto K, Narumi Y, Kiyama S.
-
Journal Title
Int J Oncol.
Volume: 44
Issue: 6
Pages: 1895-1903
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Presentation] The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinom2015
Author(s)
Shigeru Sakano, Tomoaki Takai, Kazumasa Komura, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Kazuhiro Nagao, Ryo Inoue, Kiyoshi Takahara, Hideyasu Matsuyama, Haruhito Azuma
Organizer
American Urological Association's 2015 Annual Meeting
Place of Presentation
NewOrleansMorialConventionCenter(NewOrleans USA)
Year and Date
2015-05-15
Related Report
Int'l Joint Research
-
-