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Development of a novel urethral reconstruction with tissue engineering

Research Project

Project/Area Number 26670708
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionNational Defense Medical College

Principal Investigator

TOSHIHIRO Kushibiki  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (30403158)

Co-Investigator(Kenkyū-buntansha) HORIGUCHI Akio  防衛医科大学校, 泌尿器科学講座, 講師 (20286553)
AZUMA Ryuichi  防衛医科大学校, 形成外科学講座, 講師 (00531112)
Project Period (FY) 2014-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords尿道再建 / 生体材料 / 上皮細胞 / 尿道再建術 / 口腔粘膜組織
Outline of Final Research Achievements

The purpose of this research is to develop a new urethral reconstruction using a small mouth mucosal tissue and cell scaffold material to severe urethral stricture. Broad mouth mucosal tissue is being used as the substitute tissue for an urethral stricture, but the invasiveness to a patient is high and the risk of complications is also increased. In this study, we isolated epithelium cells from a small oral mucosal tissue and tried the identification of the factor which was necessary for the cells viability. As a result, insulin of appropriate concentration was essential to the increase of the human oral mucosal epithelium cells. It was thought that it was necessary to form an epithelium cell layer using the materials which sustained release insulin for the urethral reconstruction.

Report

(2 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (10 results)

All 2015 2014

All Journal Article (1 results) Presentation (9 results) (of which Invited: 2 results)

  • [Journal Article] 外傷性尿道狭窄症に対する低侵襲治療の限界2014

    • Author(s)
      堀口明男、淺野友彦
    • Journal Title

      泌尿器外科

      Volume: 27(増刊号) Pages: 691-693

    • Related Report
      2014 Annual Research Report
  • [Presentation] 尿道形成術による勃起機能の変化に関する検討2015

    • Author(s)
      大久保和樹、堀口明男、新地祐介、杉野智啓、田地一欽、古賀章郎、辻博隆、黒田健司、佐藤全伯、朝隈純一、瀬口健至、伊藤敬一、淺野友彦
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2015-04-18 – 2015-04-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 要因からみた尿道狭窄症の治療戦略2015

    • Author(s)
      堀口明男
    • Organizer
      西埼玉地区泌尿器科スモールミーティング
    • Place of Presentation
      埼玉
    • Year and Date
      2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 要因からみた尿道狭窄症の治療戦略2014

    • Author(s)
      堀口明男
    • Organizer
      第9回岡山泌尿器科手術手技研究会
    • Place of Presentation
      岡山
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 後部尿道外傷に対する尿道形成術後の尿禁制に関する検討2014

    • Author(s)
      堀口明男、東隆一、辻田裕二郎、磯野誠、新地祐介、黒田健司、伊藤敬一、淺野友彦
    • Organizer
      第21回日本排尿機能学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 外傷性尿道狭窄症に対する待機的尿道形成術の治療成績2014

    • Author(s)
      堀口明男、東隆一、新地祐介、辻田裕二郎、黒田健司、佐藤全伯、朝隈純一、伊藤敬一、瀬口健至、淺野友彦
    • Organizer
      第11回泌尿器科再建再生研究会
    • Place of Presentation
      青森
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 外傷性尿道狭窄症に対する待機的尿道形成術の治療経験2014

    • Author(s)
      堀口明男
    • Organizer
      第28回日本外傷学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-25 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 重度の男性尿失禁に対する人工尿道括約筋AMS800埋め込み術の検討2014

    • Author(s)
      川口真、堀口明男、辻田裕二郎、伊藤敬一、東隆一、淺野友彦
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尿道狭窄症に対する尿道形成術 -単一施設110例の治療経験-2014

    • Author(s)
      堀口明男、東隆一、田崎新資、濱田真輔、辻田裕二郎、新地祐介、黒田健司、佐藤全伯、朝隈純一、瀬口健至、伊藤敬一、淺野友彦
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尿道外傷手術のトラブルシューティング -骨盤骨折による後部尿道外傷に対する待機的尿道形成術の実際2014

    • Author(s)
      堀口明男、淺野友彦
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2016-06-03  

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