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Does post-menopausal endometrioid endometrial carcinoma occur in de novo and form endometrial hyperplasia in the neighborhood?

Research Project

Project/Area Number 26670711
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

Ito Kiyoshi  東北大学, 災害科学国際研究所, 教授 (70241594)

Co-Investigator(Kenkyū-buntansha) 鈴木 貴  東北大学, 医学系研究科, 教授 (10261629)
三木 康宏  東北大学, 災害科学国際研究所, 講師 (50451521)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsestrogen / 子宮内膜癌 / 子宮内膜増殖症 / androgen / dihydrotestosterone / 5α-reductase / 17β-HSD / 閉経後 / endometrial carcinoma / endometrial hyperplasia / androgen receptor / 17β-HSD2
Outline of Final Research Achievements

We indicated that estrogen-dependent carcinoma progression is suppressed by dihydrotestosterone (DHT)-androgen receptor pathway in post-menopausal endometrioid endometrial carcinoma. Among the enzymes required for local biosynthesis of androgen, 5α-reductase type1 is the principal enzyme in the formation of DHT in endometrial carcinoma. The expression of this enzyme may play the important role for suppressing the carcinoma progression. In addition, We found that 17β-hydroxysteroid dehydrogenase type2, which catalyzes E2 to E1, is induced by DHT in post-menopausal endometrioid endometrial carcinoma.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (17 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Retinoic acid receptor beta: a potential therapeutic target in retinoic acid treatment of endometrial cancer2017

    • Author(s)
      Tsuji K, Utsuomiya H, Miki Y, Hanihara M, Fue M, Takagi K, Nishimoto M, Suzuki F, Yaegashi N, Suzuki T, Ito K
    • Journal Title

      Internatioal Journal of Gynecologic Cancer

      Volume: 印刷中 Issue: 4 Pages: 643-650

    • DOI

      10.1097/igc.0000000000000995

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In situ androgen and estrogen biosynthesis in endometrial cancer: focus on androgen actions and intratumoral production.2016

    • Author(s)
      Ito K, Miki Y, Suzuki T, McNamara KM, Sasano H.
    • Journal Title

      Endocr Relat Cancer.

      Volume: 23 Issue: 7 Pages: 323-335

    • DOI

      10.1530/erc-15-0470

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nucleobindin 2 (NUCB2) in human endometrial carcinoma: a potent prognostic factor associated with cell proliferation and migration2016

    • Author(s)
      Takagi K, Miki Y, Tanaka S, Hashimoto C, Watanabe M, Sasano H, Ito K, Suzuki T
    • Journal Title

      Endocrine Journal

      Volume: 63 Issue: 3 Pages: 287-299

    • DOI

      10.1507/endocrj.EJ15-0490

    • NAID

      130005140784

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Androgen receptor and intracrine androgen signaling in endometrial carcinomas.2015

    • Author(s)
      Miki Y , Fue M, Takagi K, Hashimoto C, Tanaka S, Suzuki. T, Ito K.
    • Journal Title

      Receptors and Clinical Investigation

      Volume: 2

    • DOI

      10.14800/rci.853

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] How do Japanese gynecologists view hormone replacement therapy for survivors of endometrial cancer? Japanese Gynecologic Oncology Group (JGOG) survey.2015

    • Author(s)
      Yokoyama Y, Ito K, Takamatsu K, Takehara K, Nakanishi T, Harano K, Watari H, Susumu N, Aoki D, Saito T.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 20 Issue: 5 Pages: 997-1004

    • DOI

      10.1007/s10147-015-0808-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma.2015

    • Author(s)
      Tanaka S, Miki Y, Hashimoto C, Takagi K, Doe Z, Li B, Yaegashi N, Suzuki T, Ito K.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 401 Pages: 56-64

    • DOI

      10.1016/j.mce.2014.11.022

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization of corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human endometrial carcinoma: CRHR1 as a potent prognostic factor.2014

    • Author(s)
      Sato N, Takagi K, Suzuki T, Miki Y, Tanaka S, Nagase S, Warita H, Fukudo S, Sato F, Sasano H, Ito K.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 24 Issue: 9 Pages: 1549-1557

    • DOI

      10.1097/igc.0000000000000269

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The 17β-hydroxysteroid dehydrogenase type 2 expression induced by the androgen signal2017

    • Author(s)
      Hashimoto C, Miki Y, Sota Tanaka S, Takagi K, Fue M, Doe Z, Li B, Suzuki T, Ito K, Yaegashi N
    • Organizer
      Society for reproductive investigation (SRI) 64th annual scientific meeting
    • Place of Presentation
      Orland、USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 子宮体がん-閉経後に急増するがんの疫学と病因-2016

    • Author(s)
      伊藤 潔、三木康宏
    • Organizer
      第16回日本抗加齢医学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 子宮内膜癌におけるコルチゾールの意義2016

    • Author(s)
      三木康宏、笛未崎、高木清司、橋本千明、鈴木貴、伊藤潔
    • Organizer
      第21回特定非営利活動法人東北内分泌研究会
    • Place of Presentation
      東北大学医学部艮陵会館(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Retinoic acid receptor β: a potential therapeutic target in retinoic acid treatment of endometrial cancer2016

    • Author(s)
      Tsuji K, Utsunomiya H, Hashimoto C, Ito K, Yaegashi N
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 子宮内膜癌組織におけるコルチゾールによるaromataseの誘導2016

    • Author(s)
      三木康宏、笛未崎、高木清司、鈴木貴、笹野公伸、伊藤潔
    • Organizer
      第17回ホルモンと癌研究会
    • Place of Presentation
      倉敷アイビースクエア(岡山県倉敷市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of relaxin on endometrial cancer malignancy2016

    • Author(s)
      Fue M, Miki Y, Takagi K, Suzuki T, Ito K
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effect of intratumoral cortisol on aromatase expression in cancer stromal cells of endometrial carcinoma2016

    • Author(s)
      Miki Y, M. Fue M, Takagi K, Suzuki T, Sasano H, Ito K
    • Organizer
      Endocrine Society 98th (ENDO)
    • Place of Presentation
      Boston、USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 子宮内膜癌組織におけるコルチゾール濃度とエストロゲン合成との関係2015

    • Author(s)
      三木康宏、笛未崎、高木清司、鈴木貴、伊藤潔
    • Organizer
      第19回東北内分泌研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Involvement of the stress hormone, cortisol, in the progression of endometrial cancer2015

    • Author(s)
      Miki Y, Fue M, Takagi K, Suzuki T, Sasano H, Ito K
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of relaxin on endometrial cancer cell proliferation and invasion through differential pathways2015

    • Author(s)
      Fue M, Miki Y, Takagi K, Suzuki T, Sasano H, Ito K
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 子宮内膜癌における17β-Hydroxysteroid Dehydrogenase type2の発現に対するアンドロゲンの影響2015

    • Author(s)
      橋本千明、三木康宏、笛 未崎、Li Bin,Doe Zhulanqiqige、田中創太、高木清司、鈴木 貴、八重樫伸生、伊藤 潔
    • Organizer
      第16回ホルモンと癌研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 類内膜型子宮内膜腺癌においてアンドロゲンはどのような作用を持つか?:アンドロゲン合成酵素5αリダクターゼ1を中心とした検討2015

    • Author(s)
      田中創太、橋本千明、李賓、伊藤潔、八重樫伸生
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Cortisol and S100P in human endometrial carcinoma2015

    • Author(s)
      Miki Y, Fue M, Hasegawa M, Takagi K, Suzuki T,Sasano H, Ito K
    • Organizer
      The Endocrine Society's of 97th Annual Meeting(ENDO2015)
    • Place of Presentation
      USA,San Diego
    • Year and Date
      2015-03-07
    • Related Report
      2014 Research-status Report
  • [Presentation] ストレスホルモンと子宮内膜癌2014

    • Author(s)
      三木康宏、高木清司、鈴木貴、笹野公伸、伊藤潔
    • Organizer
      第15回ホルモンと癌研究会
    • Place of Presentation
      仙台
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 子宮内膜癌におけるNUCB2の意義2014

    • Author(s)
      高木清司、三木康宏、田中創太、八重樫伸生、笹野公伸、伊藤潔、鈴木貴
    • Organizer
      第15回ホルモンと癌研究会
    • Place of Presentation
      仙台
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 類内膜型の子宮内膜癌における腫瘍組織中DHT濃度に関連した5αリダクターゼ1の意義2014

    • Author(s)
      田中創太、三木康宏、橋本千明、高木清司、鈴木貴、八重樫伸生、伊藤潔
    • Organizer
      第15回ホルモンと癌研究会
    • Place of Presentation
      仙台
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Intratumoral concentration of stress hormone, cortisol in endometrial carcinoma2014

    • Author(s)
      Miki Y, Takagi K, Suzuki T,Ito K
    • Organizer
      16th International Congress of Endocrinology and The Endocrine Society's of 96th Annual Meeting(ICE/ENDO2014)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-06-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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