Physiological roles of hypoxia and hypoxia inducible factor in embryo implantation
Project/Area Number |
26670714
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | The University of Tokyo |
Principal Investigator |
OSUGA YUTAKA 東京大学, 医学部附属病院, 教授 (80260496)
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Co-Investigator(Kenkyū-buntansha) |
HIROTA Yasushi 東京大学, 医学部附属病院, 講師 (40598653)
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Project Period (FY) |
2014-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | 低酸素 / 低酸素誘導因子 / 着床 / 転写調節 / 妊娠 / マウスモデル |
Outline of Final Research Achievements |
Although it has been reported that human pregnant endometrium is in hypoxic condition, it remains unclear whether hypoxia is important for successful implantation. The aim of this study is to evaluate the role of hypoxia and hypoxia inducible factor, a major transcriptional factor induced by hypoxia, in embryo implantation. We found that the mouse endometrium is in hypoxic condition in the periimplantation period, and that mouse HIF2a is critical for embryo implantation, especially in embryo attachment and decidualization. These findings suggest that endometrial hypoxia may induce HIF2a and accomplish successful implantation.
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Report
(2 results)
Research Products
(7 results)
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[Journal Article] Application of detergents or high hydrostatic pressure as decellularization process in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models2014
Author(s)
E.G.Santoso, K.Yoshida, Y.Hirota, M.Aizawa,O.Yoshino, A.Kishida, Y.Osuga, S.Saito, T.Ushida, K.S.Furukawa,
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Journal Title
PLoS ONE
Volume: 9
Issue: 7
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] IL-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells.2014
Author(s)
Urata Y, Koga K, Hirota Y, Akiyama I, Izumi G, Takamura M, Nagai M, Harada M, Hirata T, Yoshino O, Kawana K, Fujii T, Osuga Y.
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Journal Title
Am J Reprod Immunol.
Volume: 72
Issue: 5
Pages: 496-503
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells.2014
Author(s)
Fu H, Wada-Hiraike O, Hirano M, Kawamura Y, Sakurabashi A, Shirane A, Morita Y, Isono W, Oishi H, Koga K, Oda K, Kawana K, Yano T, Kurihara H, Osuga Y, Fujii T.
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Journal Title
Endocrinology
Volume: 155
Issue: 8
Pages: 3079-3087
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation.2014
Author(s)
Hirofumi Haraguchi, Tomoko Saito-Fujita, Yasushi Hirota, Mahiro Egashira, Leona Matsumoto, Mitsunori Matsuo, Takehiro Hiraoka, Kaori Koga, Naoko Yamauchi, Masashi Fukayama, Amanda Bartos, Jeeyeon Cha, Sudhansu K. Dey, Tomoyuki Fujii, Yutaka Osuga.
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Journal Title
Mol Endocrinol.
Volume: 28(7)
Issue: 7
Pages: 1108-17
DOI
Related Report
Peer Reviewed
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