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Changes of intestinal microbiome of preterm labor cases and endometriosis cases by metagenome analysis.

Research Project

Project/Area Number 26670717
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Toyama

Principal Investigator

SAITO Shigeru  富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)

Co-Investigator(Kenkyū-buntansha) 山田 拓司  東京工業大学, 生命理工学院, 准教授 (10437262)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腸内細菌叢 / 早産 / 子宮内膜症 / 炎症性疾患 / 産科学 / 生殖医学
Outline of Final Research Achievements

Preterm delivery and endometriosis are classified to inflammatory diseases. Recent data demonstrate that the changes of intestinal flora are correlated with inflammatory diseases by affecting immune system. Therefore, we have studied the metagenome profile in preterm labor cases and endometriosis cases. We have not found significant changes in intestinal flora, but abundance of Escherichia/Shigella was found in some preterm labor cases, and abundance of Meganonas and decreased Parabacteroides were found in some endometriosis cases. We should clarified the relationship between patients conditions and abnormality of intestinal flora.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (42 results)

All 2017 2016 2015 2014

All Journal Article (25 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 17 results,  Acknowledgement Compliant: 4 results,  Open Access: 7 results) Presentation (17 results) (of which Int'l Joint Research: 3 results,  Invited: 15 results)

  • [Journal Article] 絨毛膜羊膜炎2017

    • Author(s)
      米田 哲, 米田徳子, 齋藤 滋.
    • Journal Title

      周産期医学

      Volume: 46 Pages: 224-225

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra-Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High-Sensitive PCR System2016

    • Author(s)
      Yoneda S, Shiozaki A, Yoneda N, Ito M, Shima T, Fukuda K, Ueno T, Niimi H, Kitajima I, Kigawa M, Saito S
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 75(4) Issue: 4 Pages: 440-50

    • DOI

      10.1111/aji.12484

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 既往早産妊婦の管理 ③細菌性腟症・持続子宮内感染の診断と治療.2016

    • Author(s)
      塩﨑 有宏. 齋藤 滋.
    • Journal Title

      臨床婦人科産科

      Volume: 70 Pages: 20-24

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 子宮内感染、炎症からみた早産の病態.2016

    • Author(s)
      齋藤 滋
    • Journal Title

      HIGHLIGHTS OF THE RSV JAPAN GROBAL EXPERTS‘ MEETING (GEM) 2016 アッヴィ合同会社

      Volume: -

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 腸内細菌と妊娠・出産2016

    • Author(s)
      塩﨑有宏、齋藤 滋.
    • Journal Title

      診断と治療

      Volume: 104 Pages: 175-180

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 子宮内感染症(臨床的絨毛膜羊膜炎)2016

    • Author(s)
      米田 哲, 福田香織, 齋藤 滋.
    • Journal Title

      ペリネイタルケア

      Volume: 新春増刊 Pages: 37-45

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Impairment of the accumulation of decidual T cells, NK cells, and monocytes, and the poor vascular remodeling of spiral arteries, were observed in oocyte donation cases, regardless of the presence or absence of preeclampsia.2016

    • Author(s)
      Nakabayashi Y, Nakashima A, Yoshino O, Shima T, Shiozaki A, Adachi T, Nakabayashi M, Okai T, Kushima M, Saito S
    • Journal Title

      J Reprod Immunol.

      Volume: 114 Pages: 65-74

    • DOI

      10.1016/j.jri.2015.07.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polymicrobial Amniotic Fluid Infection with Mycoplasma/Ureaplasma and Other Bacteria Induces Severe Intra-Amniotic Inflammation Associated with Poor Perinatal Prognosis in Preterm Labor2015

    • Author(s)
      Yoneda N, Yoneda S, Niimi H, Ueno T, Hayashi S, Ito M, Shiozaki A, Urushiyama D, Hata K, Suda W, Hattori M, Kigawa M, Kitajima I, Saito S.
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 75(2) Issue: 2 Pages: 112-25

    • DOI

      10.1111/aji.12456

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Melting temperature mapping method: A novel method for identification of unknown pathogenic microorganisms within three hours of sample of collection.2015

    • Author(s)
      Niimi H, Ueno T, Hayashi S, Abe A, Tsurue T, Mori M, Tabata H, Minami H, Goto M, Akiyama M, Yamamoto Y, Saito S, Kitajima I
    • Journal Title

      Scientific Reports.

      Volume: 5 Issue: 1 Pages: 12543-12543

    • DOI

      10.1038/srep12543

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Eukaryote-Made Thermostable DNA Polymerase Enables Rapid PCR-Based Detection of Mycoplasma, Ureaplasma and Other Bacteria in the Amniotic Fluid of Preterm Labor Cases.2015

    • Author(s)
      Ueno T, Niimi H, Yoneda N, Yoneda S, Mori M, Tabata T, Minami H, Saito S, Kitajima I
    • Journal Title

      PLoS One.

      Volume: 10(6) Issue: 6 Pages: 1-17

    • DOI

      10.1371/journal.pone.0129032

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of Regulatory T-Cell Subtypes in Preeclampsia.2015

    • Author(s)
      Toldi G, Vasarhelyi ZE, Rigo J Jr, Orban C, Tamassy Z, Bajnok A, Shima T, Saito S, Molvarec A
    • Journal Title

      Am J Reprod Immunol.

      Volume: 74 Issue: 2 Pages: 110-115

    • DOI

      10.1111/aji.12380

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Accurate prediction for the stage of histological chorioamnionitis before delivery by amniotic fluid IL-8 level2015

    • Author(s)
      Yoneda S, Shiozaki A, Ito M, Yoneda N, Inada K, Yonezawa R, Kigawa M, Saito S
    • Journal Title

      Am J Reprod Immunol.

      Volume: 未定 Issue: 6 Pages: 12360-12360

    • DOI

      10.1111/aji.12360

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 早産の予知・予防の新たな展開 4.早産の予知  Amniotic fluid sludgeと早産予知2015

    • Author(s)
      米田徳子,伊東雅美,齋藤 滋.
    • Journal Title

      臨床婦人科産科

      Volume: 69 Pages: 296-300

    • Related Report
      2015 Research-status Report
  • [Journal Article] 切迫早産時の羊水検査2015

    • Author(s)
      米田 哲、稲坂 淳、齋藤 滋
    • Journal Title

      産科と婦人科

      Volume: 82 Pages: 19-22

    • Related Report
      2015 Research-status Report
  • [Journal Article] 細菌性腟症と早産-腟内細菌叢ならびに腸内細菌叢との関連性について-.2015

    • Author(s)
      塩﨑 有宏、齋藤 滋
    • Journal Title

      日本女性医学学会雑誌

      Volume: 22 Pages: 236-238

    • Related Report
      2015 Research-status Report
  • [Journal Article] FuncTree: Functional Analysis and Visualization for Large-Scale Omics Data.2015

    • Author(s)
      Uchiyama T, Irie M, Mori H, Kurokawa K, Yamada T.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 5 Pages: e0126967-e0126967

    • DOI

      10.1371/journal.pone.0126967

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DomSign: a top-down annotation pipeline to enlarge enzyme space in the protein universe.2015

    • Author(s)
      Wang T, Mori H, Zhang C, Kurokawa K, Xing X, Yamada T
    • Journal Title

      BMC Bioinformatics

      Volume: 16 Issue: 1 Pages: 96-96

    • DOI

      10.1186/s12859-015-0499-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content.2015

    • Author(s)
      Inada K, Shima T, Ito M, Ushijima A, Saito S.
    • Journal Title

      J Reprod Immunol.

      Volume: 107 Pages: 10-19

    • DOI

      10.1016/j.jri.2014.09.053

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prenatal diagnosis of enterolithiasis at 18 weeks: multiple foci of intraluminal calcified meconium within echogenic bowel.2015

    • Author(s)
      Shiozaki A, Yoneda S, Iizuka T, Kusabiraki T, Ito M, Ito M, Yoneda N, Yoshimoto H, Saito S.
    • Journal Title

      J Med Ultrasonics.

      Volume: 42 Issue: 1 Pages: 113-116

    • DOI

      10.1007/s10396-014-0561-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemolytic-uremic syndrome with acute encephalopathy in a pregnant woman infected with epidemic enterohemorrhagic Escherichia coli: characteristic brain images and cytokine profiles.2015

    • Author(s)
      Ito M, Shiozaki A, Shimizu M, Saito S.
    • Journal Title

      Int J Infect Dis.

      Volume: 34 Pages: 119-121

    • DOI

      10.1016/j.ijid.2015.03.024

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple pregnancy,short cervix, part-time worker, steroid use, low educational level, and male fetus are risk factors for preterm birth in Japan: A multicenter, prospective study.2014

    • Author(s)
      Shiozaki, A., Yoneda S., Nakabayashi M., Takeda Y., Takeda S., Sugimura M., Yoshida K., Tajima A., Manabe M., Akagi K., Nakagawa S., Tada K., Imafuku N., Ogawa M., Mizunoe T., Kanayama N., Itoh H., Minoura S., Ogino M., Saito S.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40 Issue: 1 Pages: 53-61

    • DOI

      10.1111/jog.12120

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrauterine growth restriction modifies gene expression profiling in cord blood.2014

    • Author(s)
      Yoshida T, Takasaki I, Kanegane H, Inomata S, Ito Y, Tamura K, Makimoto M, Saito S, Yoshimoto Y, Miyawaki T.
    • Journal Title

      Pediatr Int.

      Volume: 56 Issue: 4 Pages: 559-565

    • DOI

      10.1111/ped.12324

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome.2014

    • Author(s)
      Shimizu M, Kuroda M, Inoue N, Konishi M, Igarashi N, Taneichi H, Kanegane H, Ito M, Saito S, Yachie A.
    • Journal Title

      Cytokine.

      Volume: 66 Pages: 1-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intestinal microbiota is different in women with preterm birth: results from terminal restriction fragment length polymorphism analysis.2014

    • Author(s)
      Shiozaki A, Yoneda S, Yoneda N, Yonezawa R, Matsubayashi T, Seo G, Saito S.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 11 Pages: e111374-e111374

    • DOI

      10.1371/journal.pone.0111374

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Compilation of copy number variants identified in phenotypically normal and parous Japanese women2014

    • Author(s)
      Migita O, Maehara K, Kamura H, Miyakoshi K, Tanaka M, Morokuma S, Fukushima K, Shimamoto T, Saito S, Sago H, Nishihama K, Abe K, Nakabayashi K, Umezawa A, Okamura K, Hata K
    • Journal Title

      J. Hum. Genet.

      Volume: 59 Issue: 6 Pages: 326-331

    • DOI

      10.1038/jhg.2014.27

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Extremely preterm delivery(超早産)をいかにして防ぐか.2017

    • Author(s)
      齋藤 滋
    • Organizer
      第45回宮城県周産期医療懇話会・第23回宮城県委託周産期医療研修会.
    • Place of Presentation
      仙台
    • Year and Date
      2017-01-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 流産、早産、妊娠高血圧症候群という三大産科疾患の病態解明と治療への試み.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第95回未来医療セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The pathophysiology of preterm birth from the view point of intestinal and vaginal microbiota.2016

    • Author(s)
      Saito S
    • Organizer
      13th Congress of the International Society for Immunology of Reproduction
    • Place of Presentation
      Erfurt, Germany
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 羊水内病原体検出システムを確立し、見えてきたこと.2016

    • Author(s)
      齋藤 滋
    • Organizer
      妊婦の感染と早産を考える会~新たな早産予防と治療戦略の確立に向けて
    • Place of Presentation
      福岡
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 切迫流早産における最新の知見.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第22回 北海道周産期研修会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] これまで謎とされてきた妊娠高血圧症候群の病因・病態を明らかにする.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第15回和歌山産婦人科病診連携研究会.
    • Place of Presentation
      和歌山
    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 早産の病態に関する最近の知見 Current topics of pathophysiology of preterm delivery.2016

    • Author(s)
      齋藤 滋
    • Organizer
      名古屋大学「大学院特論」
    • Place of Presentation
      名古屋
    • Year and Date
      2016-01-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 早産の要因と対策ー最近の知見を交えてー.2015

    • Author(s)
      齋藤 滋
    • Organizer
      日本大学医学部産婦人科学教室 教室・同窓会合同忘年会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ヒト腸内細菌代謝経路データベースの構築2015

    • Author(s)
      山田 拓司
    • Organizer
      第366回CBI学会講演会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Metabolic pathway database for Human gut microbiome2015

    • Author(s)
      山田 拓司
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 免疫学的にみた妊娠維持機構と、その破綻2015

    • Author(s)
      齋藤 滋
    • Organizer
      第133回近畿産科婦人科学会学術集会
    • Place of Presentation
      甲子園
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 免疫学的妊娠維持機構から見た自己免疫合併妊娠管理2015

    • Author(s)
      齋藤 滋
    • Organizer
      第43回日本臨床免疫学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Metabolic pathway database for Human gut microbiome2015

    • Author(s)
      Takuji Yamada
    • Organizer
      International Symposium for Frontier of Bioinformatics
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fecal metagenomic analysis of colorectal cancer cohort2015

    • Author(s)
      山田 拓司
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 早産を科学する~子宮内炎症、感染に関する最近の知見~.2015

    • Author(s)
      齋藤 滋
    • Organizer
      第28回新生児慢性肺疾患研究会.
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Pathophysiology of preeclampsia from the view point of immunology.2015

    • Author(s)
      Saito S
    • Organizer
      ISSHP European Congress
    • Place of Presentation
      Hungary
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト腸内細菌代謝機能データベースの構築2015

    • Author(s)
      山田 拓司
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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