| Project/Area Number |
26670719
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
YAGUCHI CHIZUKO 浜松医科大学, 医学部附属病院, 診療助教 (20397425)
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| Co-Investigator(Kenkyū-buntansha) |
伊東 宏晃 浜松医科大学, 医学部附属病院, 教授 (70263085)
古田 直美 浜松医科大学, 医学部附属病院, 診療助教 (80647595)
田村 直顕 浜松医科大学, 医学部附属病院, 助教 (90402370)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 胎盤病理 / 胎盤基底膜板 / 脱落膜欠損 / 子宮筋癒着 / 生殖補助医療 |
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| Outline of Final Research Achievements |
We conducted a stereological analysis of the morphological characteristics in the placental basal plate with or without ART procedures.
Placental separation in the middle of the decidual layer commonly occurs after the delivery of neonates and is also referred to as the “separation zone”. We assessed the % loss of decidua in placentas and found that it was significantly higher in the frozen thawed embryo transfer in the hormonal cycle group than in the three other groups hematoma commonly forms at the “separation zone” in the decidual layer and markedly contributes to the amount of total bleeding in deliveries
we speculated that artificial endocrinological circumstances in early pregnancy, especially frozen thawed embryo transfer in the hormonal cycle group, may cause changes in the structure and/or function of the extracellular matrix in the decidual layer, as represented by the % loss of decidua, and causatively be associated with increased bleeding in deliveries.
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