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Chemoresistance through acquision of anchorage-independent cell growth in ovarian cancer.

Research Project

Project/Area Number 26670722
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKyoto University

Principal Investigator

MISE HIROKO  京都大学, 医学(系)研究科(研究院), その他 (90725607)

Co-Investigator(Kenkyū-buntansha) Matsumura Noriomi  京都大学, 医学研究科器官外科学・婦人科学産科学, 准教授 (20452336)
Konishi Ikuo  京都大学, 医学研究科器官外科学・婦人科学産科学, 名誉教授 (90192062)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords卵巣癌 / 機能ゲノミクス / 足場非依存性増殖 / 化学療法抵抗性 / 化学療法感受性 / アノイキス抵抗性 / 機能ゲノミクススクリーニング
Outline of Final Research Achievements

It is known that anchorage-independent growth is a character of cancer cells. However, not all the cancer cells have this ability. In this study, we conducted a functional genomics screening by using an shRNA library. Then we found knockdown of ABHD2 increased the ability of anchorage-independent growth. Additionally, in both clinical samples and cell lines, suppressed expression of ABHD2 was associated with resistance to platinum. These results revealed how DNA aberrations in ovarian cancer cause cancer progression and drug resistance and would be useful to develop a new therapy and a biomarker to select drugs.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles.2016

    • Author(s)
      Murakami R, Matsumura N, Brown JB, Wang Z, Yamaguchi K, Abiko K, Yoshioka Y, Hamanishi J, Baba T, Koshiyama M, Mandai M, Yamada R, Konishi I.
    • Journal Title

      Gynecol Oncol.

      Volume: 141 Issue: 1 Pages: 49-56

    • DOI

      10.1016/j.ygyno.2016.02.027

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-a potential therapeutic target.2015

    • Author(s)
      Peng J, Yoshioka Y, Mandai M, et al
    • Journal Title

      Mol Carcinog

      Volume: Epub ahead of print Issue: 4 Pages: 1-11

    • DOI

      10.1002/mc.22283

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.2015

    • Author(s)
      Peng J, Hamanishi J, Matsumura N, Abiko K, Murat K, Baba T, Yamaguchi K, Horikawa N, Hosoe Y, Murphy SK, Konishi I, Mandai M.
    • Journal Title

      Cancer Res.

      Volume: 75 Issue: 23 Pages: 5034-5045

    • DOI

      10.1158/0008-5472.can-14-3098

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic alterations caused by HNF1β expression in ovarian clear cell carcinoma contribute to cell survival.2015

    • Author(s)
      Amano Y, Mandai M, Yamaguchi K, Matsumura N, Kharma B, Baba T, Abiko K, Hamanishi J, Yoshioka Y, Konishi I.
    • Journal Title

      Oncotarget.

      Volume: 6 Issue: 28 Pages: 26002-26017

    • DOI

      10.18632/oncotarget.4692

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer2015

    • Author(s)
      Abiko K, Matsumura N, Hamanishi J, Horikawa N, Murakami R, Yamaguchi K, Yoshioka Y, Baba T, Konishi I, Mandai M
    • Journal Title

      British Journal of Cancer

      Volume: 未確定 Issue: 9 Pages: 1501-1509

    • DOI

      10.1038/bjc.2015.101

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.2015

    • Author(s)
      Nagura M, Matsumura N, Baba T, Murakami R, Kharma B, Hamanishi J, Yamaguchi K, Abiko K, Koshiyama M, Mandai M, et al.
    • Journal Title

      Gynecol Oncol

      Volume: 136 Issue: 1 Pages: 104-111

    • DOI

      10.1016/j.ygyno.2014.11.075

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic and genetic dispositions of ovarian carcinomas.2014

    • Author(s)
      Yamaguchi K, Matsumura N, Mandai M, Baba T, Konishi I, Murphy SK.
    • Journal Title

      Oncoscience.

      Volume: 1 Pages: 574-579

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] STAT1 drives tumor progression in serous papillary endometrial cancer.2014

    • Author(s)
      Kharma B, Baba T, Matsumura N, Kang HS, Hamanishi J, Murakami R, McConechy MM, Leung S, Yamaguchi K, Hosoe Y, Yoshioka Y, Murphy SK, Mandai M, Huntsman DG, Konishi I.
    • Journal Title

      Cancer Res.

      Volume: 74 Issue: 22 Pages: 6519-6530

    • DOI

      10.1158/0008-5472.can-14-0847

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic determinants of ovarian clear cell carcinoma biology.2013

    • Author(s)
      Yamaguchi K, Huang Z, Matsumura N, Mandai M, Okamoto T, Baba T, Konishi I, Berchuck A, Murphy SK.
    • Journal Title

      Int J Cancer.

      Volume: - Issue: 3 Pages: 585-97

    • DOI

      10.1002/ijc.28701

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Functional genomics screening for anoikis resistance in serous ovarian cancer identifies a novel gene ABHD22015

    • Author(s)
      Koji Yamanoi, Noriomi Matsumura, Kaoru Abiko, Ken Yamaguchi, Yumiko Yoshioka, Jyunzo Hamanishi, Tsukasa Baba, Masafumi, Koshiyama, Ikuo Konishi
    • Organizer
      第74回日本学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 機能ゲノミクススクリーニングによる、卵巣癌のanoikis抵抗性をもたらす因子の同定2015

    • Author(s)
      山ノ井康二、松村謙臣、安彦郁、山口建、吉岡弓子、濱西潤三、馬場長、越山雅文、小西郁生、万代昌紀
    • Organizer
      第57回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      アイーナいわて県民情報交流センター(盛岡市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 卵巣癌細胞のanoikis抵抗性を指標とした機能的ゲノミクススクリーニングにより同定されたABHD2の発現低下は,卵巣癌の化学療法耐性をもたらし予後不良因子となる2015

    • Author(s)
      山ノ井 康二, 松村 謙臣, 安彦 郁, 山口 建, 吉岡 弓子, 濱西 潤三, 馬場 長, 越山 雅文, 小西 郁生
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 卵巣癌細胞のanoikis抵抗性を指標とした機能的ゲノミクススクリーニングにより同定されたABHD2の発現低下は,卵巣癌の化学療法耐性をもたらし予後不良因子となる2015

    • Author(s)
      山ノ井 康二, 松村 謙臣, 安彦 郁, 山口 建, 吉岡 弓子, 濱西 潤三, 馬場 長, 越山 雅文, 小西 郁生
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Suppression of ABHD2 causes resistance to anoikis, increase of side population and chemoresistance in ovarian cancer.2014

    • Author(s)
      山ノ井康二、松村謙臣、安彦郁、山口建、吉岡弓子、濱西潤三、馬場長、越山雅文、小西郁生
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 卵巣癌のanoikis抵抗性に関わる新規遺伝子の探索:ELAC2は化学療法耐性にも寄与する2014

    • Author(s)
      山ノ井康二、松村謙臣、安彦郁、山口建、吉岡弓子、濱西潤三、馬場長、越山雅文、小西郁生
    • Organizer
      第56回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      栃木県総合分化センター
    • Year and Date
      2014-07-17 – 2014-07-19
    • Related Report
      2014 Research-status Report
  • [Book] 「high-grade 漿液性腺癌のゲノム多様性について」 臨床婦人科産科 69巻1号2015

    • Author(s)
      松村謙臣、小西郁生
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Book] 「卵巣癌の化学療法感受性と治療個別化」 産婦人科の実際 63巻7号2014

    • Author(s)
      松村謙臣、村上隆介、小西郁生
    • Publisher
      金原出版
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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