| Project/Area Number |
26670723
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
HAMANISHI Junzo 京都大学, 医学(系)研究科(研究院), 助教 (80378736)
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| Co-Investigator(Kenkyū-buntansha) |
KONISHI Ikuo 京都大学, 大学院医学研究科, 教授 (90192062)
MATSUMURA Noriomi 京都大学, 大学院医学研究科, 准教授 (20452336)
ABIKO Kaoru 京都大学, 大学院医学研究科, 准教授 (20508246)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 卵巣がん / がん免疫抑制 / 機能ゲノミクス / 免疫療法 / がん免疫逃避 / がん免疫逃避機構 / 卵巣癌 / 免疫ゲノミクス |
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| Outline of Final Research Achievements |
We detected several immune suppressive genes, by using immunological functional-genome -screening for exploring a novel factors related to cancer immune escape in ovarian cancer. Some of these genes-transduced ovarian cancer cell line showed immunosuppressive function with co-cultured CD8+T cells. Therefore these data suggested that we found one of novel immunosuppressive mechanism in ovarian cancer via these genes. Hereafter, we will confirm this immuno- mechanism with in vivo mouse ovarian cancer model.
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