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Prevention and Classification of recurrent preterm birth using a standard protocol: A prospective multicenter study

Research Project

Project/Area Number 26670724
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

Kimura Tadashi  大阪大学, 医学系研究科, 教授 (90240845)

Co-Investigator(Kenkyū-buntansha) 冨松 拓治  大阪大学, 医学系研究科, 講師 (30346209)
金川 武司  大阪大学, 医学系研究科, 招へい准教授 (40346218)
光田 信明  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 診療局長(兼産科主任部長) (50209805)
味村 和哉  大阪大学, 医学系研究科, 助教 (50437422)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords早産 / 多施設共同臨床研究グループ / バイオマーカー / 予防医学 / データベース / 前向き研究 / ホームページ / データーベース / 既往早産 / プロゲステロン / 反復早産 / 多施設共同臨床研究 / 早産予防 / 統一した管理方針 / カウンセリング
Outline of Final Research Achievements

①Incidence and risk factors for recurrent spontaneous preterm birth at multicenter were analyzed by retrospective study. ② We have developed a system that can be managed women with a previous spontaneous preterm birth using a standard protocol at multiple facilities. ③ In order to share the database among multiple facilities, a database was created using the latest EDC (Electronic Data Capture) research data registration system REDCap (Research Electronic Data Capture). ④ We launched HP to efficiently collect target cases. ⑤ It was shown that it is difficult to use blood microRNA for new biomarkers to predict recurrent preterm birth.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) Remarks (4 results)

  • [Journal Article] Neglected shoulder presentation with foetal death managed by internal podalic version with nitroglycerine and sevoflurane.2016

    • Author(s)
      Sasano T, Tomimatsu T, Kanagawa T, Kimura T.
    • Journal Title

      J Obstet Gynaecol.

      Volume: 6 Issue: 1 Pages: 1-2

    • DOI

      10.1080/01443615.2016.1239068

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction.2016

    • Author(s)
      Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T.
    • Journal Title

      Hypertens Res

      Volume: 40(4) Issue: 4 Pages: 305-310

    • DOI

      10.1038/hr.2016.152

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Response to 'Letter to "Cervical varix complicated by placenta previa: A case report and literature review": A novel simple abdominal traction stitch (Matsubara) to hold the Bakri balloon'.2016

    • Author(s)
      Matsuzaki S, Tanaka M, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 42 Issue: 11 Pages: 1627-1628

    • DOI

      10.1111/jog.13094

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful conservative management of placenta percreta: Investigation by serial magnetic resonance imaging of the clinical course and a literature review.2016

    • Author(s)
      Sawada M, Matsuzaki S, Mimura K, Kumasawa K, Endo M, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 42 Issue: 12 Pages: 1858-1863

    • DOI

      10.1111/jog.13121

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Placenta accreta following hysteroscopic myomectomy.2016

    • Author(s)
      Tanaka M, Matsuzaki S, Matsuzaki S, Kakigano A, Kumasawa K, Ueda Y, Endo M, Kimura T.
    • Journal Title

      Clin Case Rep

      Volume: 4(6) Issue: 6 Pages: 541-544

    • DOI

      10.1002/ccr3.562

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence and risk factors for recurrent spontaneous preterm birth: A retrospective cohort study in Japan.2015

    • Author(s)
      Yamashita, M., Hayashi, S., Endo, M., Okuno, K., Fukui, O., Mimura, K., Tachibana, Y., Ishii, K., Mitsuda, N. and Kimura, T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 41 Issue: 11 Pages: 1708-14

    • DOI

      10.1111/jog.12786

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Ultrasound Indicated Cerclage を行った自然早産・中期流産既往妊婦の周産期予後2016

    • Author(s)
      稲富絢子, 林周作, 川村裕士, 山本亮, 石井桂介, 光田信明
    • Organizer
      第39回日本母体胎児医学会
    • Place of Presentation
      福島市
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Physical Examination-indicated Cerclageを施行した単胎妊娠における妊娠34週未満の早産リスク因子2016

    • Author(s)
      川村裕士, 林周作, 高岡幸, 馬淵亜希, 山本亮, 石井桂介, 光田信明
    • Organizer
      第52回日本周産期・新生児医学会
    • Place of Presentation
      富山市
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ultrasound-Indicated Cerclageを行った既往自然早産・中期流産妊婦の分娩時期と早産リスク因子の検討2016

    • Author(s)
      稲富絢子, 林周作, 川村裕士, 山本亮, 石井桂介, 光田信明
    • Organizer
      第134回近畿産科婦人科学会
    • Place of Presentation
      京都市
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Physical Examination-indicated Cerclageを施行した単胎妊娠の早産リスク因子2016

    • Author(s)
      川村裕士, 林周作, 高岡幸, 馬淵亜希, 山本亮, 石井桂介, 光田信明
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京都
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Remarks] これまでに自然早産をされたことのある妊産婦さんへ

    • URL

      https://www.mch.pref.osaka.jp/hospital/department/sanka/sanka01.html#lc05

    • Related Report
      2016 Annual Research Report
  • [Remarks] 大阪大学医学部産婦人科 | 患者様へのご案内

    • URL

      http://www.med.osaka-u.ac.jp/pub/gyne/www/html/info18.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] Japan Red Cap

    • URL

      https://rdc01.dcc.med.osaka-u.ac.jp/redcap/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 大阪府立母子保健総合医療センター リスクをお持ちの妊婦さんの管理

    • URL

      http://www.mch.pref.osaka.jp/hospital/department/sanka/sanka01.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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