Anti-aging effects of melatonin on ovarian aging
Project/Area Number |
26670726
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Yamaguchi University |
Principal Investigator |
SUGINO Norihiro 山口大学, 医学(系)研究科(研究院), 教授 (10263782)
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Co-Investigator(Kenkyū-buntansha) |
JOZAKI Kousuke 山口大学, 大学院医学系研究科, 助教 (80721323)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | メラトニン / 卵巣 / 加齢 / 酸化ストレス / 卵 |
Outline of Final Research Achievements |
Ovarian aging occurs as a result of a decrease in the number and quality of oocytes in ovarian cortex follicles. Oxidative stress is thought to be major cause of ovarian aging. However, there are no established treatments to prevent ovarian aging. Melatonin is a hormone secreted by a pineal gland, and is known as a powerful antioxidant. This study investigated whether long-term melatonin treatment can prevent ovarian aging in mice. Female ICR mice (10 weeks old) were divided into two groups: half were fed with water as a control and the other half were supplemented with 100 μg/ml melatonin water until 43 weeks. The long-term melatonin treatment prevented the age-related decreases in the number of ovulated oocytes and follicles in the ovarian tissue, fertilization rates, and embryo development. The present results indicated that melatonin prevents ovarian aging by activating both expression of ribosome-related genes and free radical scavenging network.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Tissue-specific expression of estrogen receptor 1 is regulated by DNA methylation in a T-DMR.2016
Author(s)
Maekawa R, Sato S, Okada M, Lee L, Tamura I, Jozaki K, Kajimura T, Asada H, Yamagata Y, Tamura H, Yamamoto S, Sugino N
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Journal Title
Molecular Endocrinology
Volume: 30
Pages: 335-347
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Retinoic acid has the potential to suppress endometriosis development.2015
Author(s)
Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, Sato S, Maekawa R, Taketani T, Asada H, Tamura H, Nakai A, Sugino N
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Journal Title
Journal of Ovarian Research
Volume: 8
Pages: 49-49
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Melatonin protects the integrity of granulosa cells by reducing oxidative stress in nuclei, mitochondria, and plasma membranes in mice.2015
Author(s)
Tanabe M, Tamura H, Taketani T, Okada M, Lee L, Tamura I, Maekawa R, Aasada H, Yamagata Y, Sugino N
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Journal Title
Journal of Reproduction and Development
Volume: 61
Pages: 35-41
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Locally existing endothelial cells and pericytes in ovarian stroma, but not bone marrow-derived vascular progenitor cells, play a central role in neovascularization during follicular development in mice.2014
Author(s)
Kizuka-Shibuya F, Tokuda N, Takagi K, Adachi Y, Lee L, Tamura I, Maekawa R, Tamura H, Suzuki T, Owada Y, Sugino N
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Journal Title
Journal of Ovarian Research
Volume: 7
Pages: 10-10
Related Report
Peer Reviewed / Open Access
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