| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Radiotherapy is generally used as one of treatment modalities for head and neck cancer, and it has been known to not only kill cancer cells but also induce anti-tumor immune responses through the expression of immunostimulatory molecules and release various signaling molecules. In this study, immunomodulatory effect by radiotherapy (X-ray and heavy ion radiation) was investigated using head and neck squamous cell carcinoma cell lines. Heavy ion radiation more efficiently killed tumor cells compared to X-ray. Moreover, radiotherapy could enhance calreticulin expression and decrease CD47 expression on tumor cells. These results suggest that radiotherapy might promote successful induction of anti-tumor immune responses via acceleration of phagocytosis by decrease of CD47 molecule.
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