Intravital imaging of auditory function and pathology
Project/Area Number |
26670738
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
|
Research Institution | The University of Tokyo |
Principal Investigator |
Matsumoto Yu 東京大学, 医学部附属病院, 助教 (80548553)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 生体イメージング / 耳科学 |
Outline of Final Research Achievements |
Experimental procedures such as anesthesia, surgery, fixation and fluorescent staining were optimized. Calcium imaging of the hair cells was performed upon sound stimulation. Oxidative stress was also imaged upon direct administration of antimycin A.
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Report
(3 results)
Research Products
(61 results)
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[Journal Article] Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors.2016
Author(s)
Anraku Y, Kishimura A, Kamiya M, Tanaka S, Nomoto T, Toh K, Matsumoto Y, Fukushima S, Sueyoshi D, Kano MR, Urano Y, Nishiyama N, Kataoka K.
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Journal Title
Angew Chem Int Ed Engl.
Volume: 55
Issue: 2
Pages: 560-565
DOI
Related Report
Peer Reviewed
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[Journal Article] Enhanced Efficacy against Cervical Carcinomas through Polymeric Micelles Physically Incorporating the Proteasome Inhibitor MG132.2016
Author(s)
Matsumoto Y, Miyamoto Y, Cabral H, Matsumoto Y, Nagasaka K, Nakagawa S, Yano T, Maeda D, Oda K, Kawana K, Nishiyama N, Kataoka K, Fujii T
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Journal Title
Cancer Sci
Volume: in press
Issue: 6
Pages: 773-781
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery2016
Author(s)
Yu Matsumoto, Joseph W. Nichols, Kazuko Toh, Takahiro Nomoto, Horacio Cabral, Yutaka Miura, R. James Christie, Naoki Yamada, Tadayoshi Ogura, Mitsunobu R. Kano, Yasuhiro Matsumura, Nobuhiro Nishiyama, Tatsuya Yamasoba, You Han Bae, Kazunori Kataoka
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Journal Title
Nature Nanotechnology
Volume: -
Issue: 6
Pages: 533-538
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Systemic Delivery of Sirna by Actively Targeted Polyion Complex Micelles for Silencing the E6 and E7 Human Papillomavirus Oncogenes2016
Author(s)
Nishida H, Matsumoto Y, Kawana K, Christie RJ, Naito M, Kim BS, Toh K, Min HS, Yi Y, Matsumoto Y, Kim HJ, Miyata K, Taguchi A, Tomio K, Yamashita A, Inoue T, Nakamura H, Fujimoto A, Sato M, Yoshida M, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Nishiyama N, Kataoka K, Osuga Y, Fujii T
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Journal Title
J Control Release
Volume: in press
Pages: 29-37
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy2016
Author(s)
T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama, K. Kataoka
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Journal Title
Biomater. Sci.
Volume: 印刷中
Issue: 5
Pages: 826-838
DOI
Related Report
Peer Reviewed
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[Journal Article] Density-Tunable Conjugation of Cyclic Rgd Ligands with Polyion Complex Vesicles for the Neovascular Imaging of Orthotopic Glioblastomas2015
Author(s)
Kawamura W, Miura Y, Kokuryo D, Toh K, Yamada N, Nomoto T, Matsumoto Y, Sueyoshi D, Liu X, Aoki I, Kano MR, Nishiyama N, Saga T, Kishimura A, Kataoka K
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Journal Title
Science and Technology of Advanced Materials
Volume: 16
Issue: 3
Pages: 035004-035004
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers2015
Author(s)
H. Cabral, J. Makino, Y. Matsumoto, P. Mi, H. Wu, T. Nomoto, K. Toh, N. Yamada, Y. Higuchi, S. Konishi, M.R. Kano, H. Nishihara, Y. Miura, N. Nishiyama, K. Kataoka
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Journal Title
ACS Nano
Volume: Article ASAP
Issue: 5
Pages: 4957-67
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy2014
Author(s)
H.-C. Yen, H. Cabral, P. Mi, K. Toh, Y. Matsumoto, X. Liu, H. Koori, A. Kim, K. Miyazaki, Y. Miura, N. Nishiyama, K. Kataoka
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Journal Title
ACS Nano
Volume: 8
Issue: 11
Pages: 11591-11602
DOI
Related Report
Peer Reviewed
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[Journal Article] Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation2014
Author(s)
H. Wu, H. Cabral, K. Toh, P. Mi, Y.-C. Chen, Y. Matsumoto, N. Yamada, X. Liu, H. Kinoh, Y. Miura, M. R. Kano, H. Nishihara, N. Nishiyama, K. Kataoka
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Journal Title
J. Control. Release
Volume: 189
Pages: 1-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors2014
Author(s)
Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka
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Journal Title
Biomaterials
Volume: 35
Issue: 27
Pages: 7887-7895
DOI
Related Report
Peer Reviewed
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[Journal Article] Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles2014
Author(s)
H. -J. Kim, H. Takemoto, Y. Yi, M. Zheng, Y. Maeda, H. Chaya, K. Hayashi, P. Mi, F. Pittella, R. J. Christie, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka
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Journal Title
ACS Nano
Volume: 8
Issue: 9
Pages: 8979-8991
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014
Author(s)
Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
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Journal Title
Drug Delivery and Translational Research
Volume: 4
Issue: 1
Pages: 50-60
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors2014
Author(s)
Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka
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Journal Title
Biomaterials
Volume: 35
Issue: 10
Pages: 3416-3426
DOI
Related Report
Peer Reviewed
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[Presentation] Ligand density effect on selective delivery in brain parenchyma through blood-brain barrier of glucose-linked polyion complex micelle system2014
Author(s)
Fukusato Y, Anraku Y, Mizoguchi A, Ishii T, Matsumoto Y, Toh K, Kuwahara H, Yokota T, Kataoka K
Organizer
The 10th International Polymer Conference IPC2014
Place of Presentation
International Congress Center, Tsukuba, Ibaraki
Year and Date
2014-12-05
Related Report
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[Presentation] Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation2014
Author(s)
Wu H, Cabral H, Toh K, Mi P, Matsumoto Y, Ahn JY, Kinoh H, Nishiyama N, Miura Y, Kataoka K
Organizer
The 10th International Polymer Conference IPC2014
Place of Presentation
International Congress Center, Tsukuba, Ibaraki
Year and Date
2014-12-03
Related Report
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[Presentation] 前庭症状を主訴とした症例での簡易温度刺激検査の年代別検討2014
Author(s)
畑 裕子, 山崎 葉, 堤内 亮, 山本 沙, 崎谷 恵, 一瀬 和, 馬場 美, 松本 有, 小嶋 康, 井之口 豪, 藤田 岳, 奥野 妙
Organizer
第73回日本めまい平衡医学会総会・学術講演会
Place of Presentation
パシフィコ横浜、神奈川県横浜市
Year and Date
2014-11-07
Related Report
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[Presentation] 腫瘍でクスリを「作る」酵素封入PICsomeシステムの開発2014
Author(s)
安楽泰孝, Xiao L, Cabral H, 末吉大輝, 福島重人, 松本有, 藤加珠子, 神谷真子, 浦野泰照, 岸村顕広, 西山伸宏, 片岡一則
Organizer
第63回高分子討論会
Place of Presentation
長崎大学文教キャンパス、長崎県長崎市
Year and Date
2014-09-25
Related Report
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[Presentation] 血液脳関門を効率的に通過する高分子ミセルシステムの構築2014
Author(s)
安楽泰孝, 福里優, 溝口明宏, 石井武彦, 松本有, 藤加珠子, 桑原宏哉, 新田佳子, 横田隆徳, 片岡一則
Organizer
アンチセンス・遺伝子・デリバリーシンポジウム2014
Place of Presentation
東京医科歯科大学 M&Dタワー、東京都文京区
Year and Date
2014-09-08
Related Report
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[Presentation] Toolbox of differently sized and labeled PMMA nanoparticles for cell studies2014
Author(s)
Schubert S, Vollrath A, Traeger A, Pretzel D, Pietsch C, Nomoto T, Matsumoto Y, Kataoka K, Schubert US
Organizer
248th American Chemical Society (ACS) National Meeting & Exposition
Place of Presentation
Moscone Center, San Francisco, CA, USA
Year and Date
2014-08-11
Related Report
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[Presentation] Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation2014
Author(s)
Wu H, Cabral H, 藤加珠子, Mi P, Chen YC, 松本有, 山田直生, Liu X, 喜納宏昭, 三浦裕, 狩野光伸, 西原寛, 西山伸宏, 片岡一則
Organizer
第30回日本DDS学会学術集会
Place of Presentation
慶應義塾大学芝共立キャンパス、東京都港区
Year and Date
2014-07-30
Related Report
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[Presentation] 生体における抗酸化能の可視化2014
Author(s)
松本有, 狩野章太郎, 吉川弥生, 山岨達也
Organizer
第115回日本耳鼻咽喉科学会・学術講演会
Place of Presentation
ヒルトン福岡市ーホーク、福岡県福岡市
Year and Date
2014-05-16
Related Report
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[Presentation] 前庭症状を主訴とした症例の年代別特徴について 第2報2014
Author(s)
畑裕子, 堤内亮博, 山本沙織, 一瀬和美, 松本有, 藤田岳, 小嶋康隆, 桑内麻也子, 宇野真莉子, 山崎葉子, 栗田宣彦, 奥野妙子
Organizer
第115回日本耳鼻咽喉科学会・学術講演会
Place of Presentation
ヒルトン福岡市ーホーク、福岡県福岡市
Year and Date
2014-05-15
Related Report
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[Presentation] アリナミンテストの結果に対する病態に基づいた新たな解釈2014
Author(s)
菊田周, 松本有, 坂本幸士, 近藤健二, 上羽瑠美, 岩村均, 籠谷領二, 西嶌大宣, 鈴川佳吾, 平野真希子, 山岨達也
Organizer
第115回日本耳鼻咽喉科学会・学術講演会
Place of Presentation
ヒルトン福岡市ーホーク、福岡県福岡市
Year and Date
2014-05-14
Related Report
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[Presentation] 日本語版UW-CAMP音楽聞き取り評価テスト(J-CAMP)の作成2014
Author(s)
樫尾明憲, 尾形エリカ, 赤松裕介, 柴崎仁志, 岸本めぐみ, 松本有, 坂本幸士, 狩野章太郎, 柿木章伸, 岩崎真一, 山岨達也
Organizer
第115回日本耳鼻咽喉科学会・学術講演会
Place of Presentation
ヒルトン福岡市ーホーク、福岡県福岡市
Year and Date
2014-05-14
Related Report
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[Presentation] 耳硬化症の難聴発症と側頭骨CT所見2014
Author(s)
奥野妙子, 小嶋康隆, 畑裕子, 松本有, 栗田宣彦, 堤内亮博, 山本沙織, 一瀬和美
Organizer
第115回日本耳鼻咽喉科学会・学術講演会
Place of Presentation
ヒルトン福岡市ーホーク、福岡県福岡市
Year and Date
2014-05-14
Related Report
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