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Exploration of new treatment for intractable upper airway inflammatory diseases using functional immune complexes

Research Project

Project/Area Number 26670742
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionOkayama University

Principal Investigator

Okano Mitsuhiro  岡山大学, 医歯(薬)学総合研究科, 准教授 (60304359)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords黄色ブドウ球菌 / プロテインA / IgG / IFN-γ / IL-10 / IL-5 / 単球 / 免疫複合体
Outline of Final Research Achievements

Functional immune complexes consisting of Staphylococcal protein A (SpA) from S. aureus and immunoglobulins regulate type 2 inflammatory reaction including IL-5 and IL-13 production via several mechanisms such as IL-10 release. In addition, SpA-IgG immune complexes induced an expression of anti-inflammatory molecule X on monocytes. An antagonist for molecule X reversed the inhibitory effect of SpA-IgG immune complexes on staphylococcal enterotoxin B-induced cytokine production by nasal polyp cells. These results suggest that the induction of molecule X is one of the major mechanisms how this functional immune complexes show anti-inflammatory effect on upper airway inflammation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 8 results,  Acknowledgement Compliant: 5 results) Presentation (7 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression.2016

    • Author(s)
      Noyama Y, Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Makihara S, Kanai K, Koyama T, Taniguchi M, Ishitoya J, Kanda A, Kobayashi Y, Asako M, Tomoda K, Nishizaki K.
    • Journal Title

      Allergology International

      Volume: 印刷中

    • NAID

      130005308495

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts.2016

    • Author(s)
      Kanai K, Okano M, Fujiwara T, Kariya S, Haruna T, Omichi R, Makihara S, Hirata Y, Nishizaki K.
    • Journal Title

      Allergology International

      Volume: 印刷中 Issue: 4 Pages: 414-419

    • DOI

      10.1016/j.alit.2016.03.003

    • NAID

      130005431326

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps2016

    • Author(s)
      Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, Noyama Y, Koyama T, Omichi R, Orita Y, Miki K, Kanai K, Nishizaki K.
    • Journal Title

      Allergology International

      Volume: 65 Issue: 1 Pages: 96-102

    • DOI

      10.1016/j.alit.2015.08.005

    • NAID

      130005290330

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pulmonary function in never-smoker patients with chronic rhinosinusitis.2015

    • Author(s)
      Kariya S, Okano M, Higaki T, Noyama Y, Haruna T, Nishizaki K.
    • Journal Title

      International Forum of Allergy and Rhinology

      Volume: 5 Issue: 11 Pages: 990-995

    • DOI

      10.1002/alr.21628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps.2015

    • Author(s)
      Okano M, Fujiwara T, Kariya S, Haruna T, Higaki T, Noyama Y, Makihara SI, Kanai K, Nishizaki K.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: ━ Issue: 2 Pages: 343-350

    • DOI

      10.1016/j.jaci.2014.10.058

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic rhinosinusitis patients have decreased lung function.2014

    • Author(s)
      Kariya S, Okano M, Higaki T, Noyama T, Haruna T, Ishihara T, MakinoT, Onoda T, Nishizaki K.
    • Journal Title

      International Forum of Allergy and Rhinology

      Volume: 4 Issue: 10 Pages: 828-833

    • DOI

      10.1002/alr.21370

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps.2014

    • Author(s)
      Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Matsushita O, Noda Y, Makihara S, Kanai K, Noyama Y, Taniguchi M, Nishizaki K.
    • Journal Title

      Allergology International

      Volume: 63 Pages: 563-573

    • NAID

      130004705227

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis.2014

    • Author(s)
      Kariya S, Okano M, Oto T, Higaki T, Makihara S, Haruna T, Nishizaki K.
    • Journal Title

      Journal of Laryngology and Otology

      Volume: 128 Issue: 3 Pages: 255-262

    • DOI

      10.1017/s0022215114000450

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Local expression of IL-17A is correlated with nasal eosinophilia and clinical severity in allergic rhinitis.2014

    • Author(s)
      Makihara S, Okano M, Fujiwara T, Noda Y, Higaki T, Miyatake T, Kanai K, Haruna T, Kariya S, Nishizaki K.
    • Journal Title

      Allergy and Rhinology

      Volume: 5 Issue: 1 Pages: 22-27

    • DOI

      10.2500/ar.2014.5.0078

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps2015

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
    • Place of Presentation
      パナマシティ(パナマ)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crosstalk of Staphylococcus aureus-derived components and COX metabolism in the pathogenesis of CRS2015

    • Author(s)
      Mitsuhiro Okano, Takenori Haruna and Kengo Kanai
    • Organizer
      Rhinology Research Forum in Asia
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chronic rhinosinusitis and lung function2015

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      World Congress of Rhinology
    • Place of Presentation
      サンパウロ(ブラジル)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps2015

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      Korean International Congress of Otorhinolaryngology Head and Neck Surgery
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps2015

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      Asian Research Symposium in Rhinology
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 黄色ブドウ球菌プロテインA-免疫複合体による免疫制御2015

    • Author(s)
      岡野光博、假谷伸、檜垣貴哉、春名威範、野山和廉、小山和久、金井健吾、牧原靖一郎、西﨑和則
    • Organizer
      第33回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-26 – 2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 黄色ブドウ球菌コンポーネントによる好酸球性副鼻腔炎の制御-“黄色ブドウ球菌理論(Staph. aureus theory)-2014

    • Author(s)
      岡野光博
    • Organizer
      第33回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Book] 今日の治療指針2016

    • Author(s)
      岡野光博
    • Total Pages
      2096
    • Publisher
      中山書店
    • Related Report
      2015 Annual Research Report
  • [Book] EBM 耳鼻咽喉科・頭頸部外科の治療 2015-20162015

    • Author(s)
      岡野光博、金井健吾
    • Total Pages
      687
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] インターロイキン10産生促進剤2015

    • Inventor(s)
      岡野光博、西﨑和則、藤原田鶴子
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-03-19
    • Related Report
      2014 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2017-05-10  

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