Exploration of new treatment for intractable upper airway inflammatory diseases using functional immune complexes
| Project/Area Number |
26670742
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
Okano Mitsuhiro 岡山大学, 医歯(薬)学総合研究科, 准教授 (60304359)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 黄色ブドウ球菌 / プロテインA / IgG / IFN-γ / IL-10 / IL-5 / 単球 / 免疫複合体 |
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| Outline of Final Research Achievements |
Functional immune complexes consisting of Staphylococcal protein A (SpA) from S. aureus and immunoglobulins regulate type 2 inflammatory reaction including IL-5 and IL-13 production via several mechanisms such as IL-10 release. In addition, SpA-IgG immune complexes induced an expression of anti-inflammatory molecule X on monocytes. An antagonist for molecule X reversed the inhibitory effect of SpA-IgG immune complexes on staphylococcal enterotoxin B-induced cytokine production by nasal polyp cells. These results suggest that the induction of molecule X is one of the major mechanisms how this functional immune complexes show anti-inflammatory effect on upper airway inflammation.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression.2016
Author(s)
Noyama Y, Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Makihara S, Kanai K, Koyama T, Taniguchi M, Ishitoya J, Kanda A, Kobayashi Y, Asako M, Tomoda K, Nishizaki K.
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Journal Title
Allergology International
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps2016
Author(s)
Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, Noyama Y, Koyama T, Omichi R, Orita Y, Miki K, Kanai K, Nishizaki K.
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Journal Title
Allergology International
Volume: 65
Issue: 1
Pages: 96-102
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps.2014
Author(s)
Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Matsushita O, Noda Y, Makihara S, Kanai K, Noyama Y, Taniguchi M, Nishizaki K.
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Journal Title
Allergology International
Volume: 63
Pages: 563-573
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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