| Project/Area Number |
26670743
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Ehime University |
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Principal Investigator |
HATO NAOHITO 愛媛大学, 医学(系)研究科(研究院), 教授 (60284410)
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| Co-Investigator(Renkei-kenkyūsha) |
Takagi Daiki 愛媛大学, 大学院医学系研究科, 助教 (10448376)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 真珠腫 / Galectin-7 / 内耳毒性 / 免疫染色 / galectin-7 / 蛍光染色 |
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| Outline of Final Research Achievements |
Galectin-7, a member of lectin family, contributes to different events associated with the differentiation and development of pluristratified epithelia. By proteomic analysis of middle ear cholesteatoma obtained at operation, we found galectin-7 as a specific protein constituting cholesteatoma. As galectin 7 could be detected in cholesteatoma matrix but not in middle ear mucosa, it might be a good marker of the residue in surgery of middle ear cholesteatoma. Residue of the matrix is considered a main cause of cholesteatoma recurrence. Therefore, detection of galectin-7 by immunofluorescent staining method would be an useful procedure in detecting presence of residual cholestetoma.
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