development of new treatment against head and neck cancer using lactobacillus casei
Project/Area Number |
26670747
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
|
Research Institution | Iwate Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
志賀 清人 岩手医科大学, 医学部, 教授 (10187338)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | lactobacillus casei / head and neck SCC / antitumor activity / obligate anaerobe / 頭頸部扁平上皮癌 / 乳酸菌抗腫瘍効果 |
Outline of Final Research Achievements |
We injected obligate anaerobe strains of Lactobacillus casesi in the squamous cell carcinoma transplanted on mouse subctaneous tissue, and antitumor effect of Lactobacillus casei was observed. This effect was not observed with dead cells of lactobacillus casei. We considered this effect was the result of the immunostimulation by the proliferating bacteria in the tumor.
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Report
(4 results)
Research Products
(2 results)