development of new treatment against head and neck cancer using lactobacillus casei

Research Project

Project/Area Number	26670747
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Iwate Medical University
Principal Investigator	Katagiri Katsunori 岩手医科大学, 医学部, 助教 (10455842)
Co-Investigator(Kenkyū-buntansha)	志賀清人岩手医科大学, 医学部, 教授 (10187338)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	lactobacillus casei / head and neck SCC / antitumor　activity / obligate anaerobe / 頭頸部扁平上皮癌 / 乳酸菌抗腫瘍効果
Outline of Final Research Achievements	We injected obligate anaerobe strains of Lactobacillus casesi in the squamous cell carcinoma transplanted on mouse subctaneous tissue, and antitumor effect of Lactobacillus casei was observed. This effect was not observed with dead cells of lactobacillus casei. We considered this effect was the result of the immunostimulation by the proliferating bacteria in the tumor.

Report

(4 results)