| Project/Area Number |
26670757
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
Yoshida Shigeo 九州大学, 医学(系)研究科(研究院), 准教授 (50363370)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI TATSURO 九州大学, 大学病院, 病院長 (30150428)
星野 友 九州大学, 工学(系)研究科(研究院), 准教授 (40554689)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSHINO YU 九州大学, 工学研究院, 准教授 (40554689)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | プラスチック抗体 / 網膜血管新生 / 脈絡膜血管新生 / ペリオスチン / ナノ粒子 / 血管新生 |
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| Outline of Final Research Achievements |
We synthesized polymer nanoparticle libraries and performed screening to extract those polymer particles to inhibit periostin-dependent cell proliferation using in vitro cell proliferation assays. At the 2nd screening, we could extract Cation1-4, Cation1-5, Cation1-6 which inhibited cell proliferation in a dose-dependent manner. Among these polymer nanoparticles, Cation1-4 exhibited the significant inhibition of retinal and choroidal proliferation in vivo.
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