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Analysis of genomic aberrations, risk of secondary cancer development and, hereditary effects by irradiation and chemotherapy in children

Research Project

Project/Area Number 26670764
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatric surgery
Research InstitutionHiroshima University

Principal Investigator

HIYAMA Eiso  広島大学, 自然科学研究支援開発センター, 教授 (00218744)

Co-Investigator(Kenkyū-buntansha) ONITAKE Yoshiyuki  広島大学, 大学病院, 病院助教 (10448269)
KURIHARA Sho  広島大学, 大学病院, 医科診療医 (40724894)
Project Period (FY) 2014-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsゲノム / 癌 / マイクロアレイ / 小児 / 放射線
Outline of Final Research Achievements

Genomic aberration was analyzed in 27 childhood cancer survivors who underwent treatments in Hiroshima University Hospital after 1980 and could have their own children. Among them, 15 cases had genomic aberrations which were significantly correlated to whole body irradiation and high-dose chemotherapy in their history. The analysis of these aberrations in their children suggested the possibility that hereditary transmission occurred in 3 cases but the common characteristics were not identified in these 3 cases. And in 5 of 6 cases who had secondary malignancies had genomic aberrations.
These results revealed that genomic aberration due to cancer treatments were identified in the childhood cancer survivors and some of them were transmitted in their children.

Report

(2 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (24 results)

All 2015 2014

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (15 results) Book (1 results)

  • [Journal Article] 肝芽腫の分子生物学2015

    • Author(s)
      檜山英三, 上田祐華, 栗原 将
    • Journal Title

      小児外科

      Volume: 47 Pages: 181-188

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Children’s Hepatic tumors International Collaboration (CHIC): novel global rare tumor database yields new prognostic factors in hepatoblastoma2015

    • Author(s)
      Czauderna P, Haeberle B, Hiyama E
    • Journal Title

      Lancet

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy2014

    • Author(s)
      Czauderna P, Lopez-Terrada D, Hiyama E, Häberle B, Malogolowkin MH, Meyers RL
    • Journal Title

      Current Opinion in Pediatrics

      Volume: 26 Issue: 1 Pages: 19-28

    • DOI

      10.1097/mop.0000000000000046

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium2014

    • Author(s)
      Lopez-Terrada D, Alaggio R, de Davila MT, Czauderna P, Hiyama E, Katzenstein H, Leuschner I, Malogolowkin M, Meyers R, Ranganathan S, Tanaka Y, Tomlinson G, Fabre M, Zimmermann A, Finegold MJ; Children's Oncology Group Liver Tumor Committee
    • Journal Title

      Modern Pathology

      Volume: 27 Issue: 3 Pages: 472-491

    • DOI

      10.1038/modpathol.2013.80

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経芽細胞腫マススクリーニングの最近の動向 パネルディスカッション「神経芽腫マススクリーニングを考える」2014

    • Author(s)
      檜山英三
    • Journal Title

      日本マス・スクリーニング学会誌

      Volume: 24 Pages: 221-226

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of ATRX or DAXX mutated neuroblastoma2014

    • Author(s)
      Kurihara S, Hiyama E, Onitake Y, Yamaoka E, Hiyama K
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 49 Issue: 12 Pages: 1835-1838

    • DOI

      10.1016/j.jpedsurg.2014.09.029

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions2014

    • Author(s)
      Tokumasu D, Sakuma T, Hayashi Y, Hosoi S, Hiyama E, Yamamoto T
    • Journal Title

      Genes to Cells

      Volume: 19 Issue: 5 Pages: 419-431

    • DOI

      10.1111/gtc.12142

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pediatric Hepatoblastoma: diagnosis and treatment2014

    • Author(s)
      Hiyama E
    • Journal Title

      Translational Pediatrics

      Volume: 3 Pages: 293-299

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 転移を有した肝芽腫6例の外科的検討2014

    • Author(s)
      栗原 将, 鬼武美幸, 三木瑞香, 中村和洋, 小林正夫, 檜山英三
    • Organizer
      第56回日本小児血液・がん学会学術集会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-11-28 – 2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular diagnosis of lung cancer2014

    • Author(s)
      Hiyama E.
    • Organizer
      APSR2014
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Outcome and morbidity of primary resection of hepatoblastoma in JPLT-1 and 2 protocols2014

    • Author(s)
      Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S.
    • Organizer
      SIOP2014
    • Place of Presentation
      Tronto, Canada
    • Year and Date
      2014-10-22 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小児固形腫瘍における循環遊離DNAと循環がん細胞のがん診断への応用2014

    • Author(s)
      檜山英三, 檜山桂子, 林 陽子, 森原なぎさ, 平野尚子, 福場郁子, 山岡絵美, 栗原 将
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNAメチル化解析による肝芽腫の新規予後予測マーカーの確立2014

    • Author(s)
      本多昌平, 湊 雅嗣, 鈴木 拓, 春田雅之, 金子安比古, 檜山英三, 武冨紹信
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経芽腫マス・スクリーニング休止後の臨床像の変化-小児の外科的悪性腫瘍登録データの解析より-2014

    • Author(s)
      米田光宏,田尻達郎,伊勢一哉,大植孝治,小野  滋,佐藤智行,杉藤公信,菱木知郎,平井みさ子,文野誠久,本多昌平,風間道郎,杉山正彦,中田光政,仲谷健吾,脇坂宗親,近藤知史,上原秀一郎,鬼武美幸,木下義晶,米倉竹夫,檜山英三,家原知子
    • Organizer
      第41回日本マススクリーニング学会
    • Place of Presentation
      広島市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 門脈大循環シャントによるガラクトース血症の治療2014

    • Author(s)
      檜山英三, 栗原 将, 鬼武美幸, 但馬 剛, 西村 裕, 佐倉伸夫
    • Organizer
      第41回日本マススクリーニング学会
    • Place of Presentation
      広島市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] NBマス開始前後の変化レトロスペクティブ解析結果2014

    • Author(s)
      檜山英三
    • Organizer
      第41回日本マススクリーニング学会
    • Place of Presentation
      広島市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Surgical managements for refractory neuroblastoma in young children2014

    • Author(s)
      Hiyama E, Kurihara S, Onitake Y, Ueda Y, Miki M, Kawaguchi H, Nakamura K, Kobayashi M
    • Organizer
      BAPS61st Annual Congress
    • Place of Presentation
      Edinburgh, Scotland
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Central venous catheter-related complications in children with malignancy2014

    • Author(s)
      Kurihara S, Hiyama E, Onitake Y, Miki M, Nakamura K, Kawaguchi H, Kobayashi M
    • Organizer
      PAPS2014
    • Place of Presentation
      Calgary, Canada
    • Year and Date
      2014-05-25 – 2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] linical feature of ATRX or DAXX mutated neuroblastoma2014

    • Author(s)
      Hiyama E, Kurihara S, Onitake Y, Yamaoka E, Fukuba I, Hiyama K
    • Organizer
      PAPS2014
    • Place of Presentation
      Calgary, Canada
    • Year and Date
      2014-05-25 – 2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Telomere Biology in Neuroblastoma: Focusing on ATRX/DAXX Genes and Alternative-Strengthening of Telomere(ALT)2014

    • Author(s)
      Hiyama E
    • Organizer
      ANR Congress 2014
    • Place of Presentation
      Cologne, Germany
    • Year and Date
      2014-05-13 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] JPLT(肝芽腫)2014

    • Author(s)
      檜山 英三
    • Organizer
      第51回日本小児外科学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection of Cancer Stem Cells in Childhood Cancers2014

    • Author(s)
      Hiyama E
    • Organizer
      BIT’S 4th Annual World Congress of Molegular & Cel
    • Place of Presentation
      Dailen, China
    • Year and Date
      2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 芽腫の縦隔再発に対してICG蛍光法を使用した経験2014

    • Author(s)
      栗原 将, 鬼武美幸, 小倉 薫, 檜山英三
    • Organizer
      第55回日本中国四国小児がん研究会
    • Place of Presentation
      広島県福山市
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Book] 肝芽腫の診断と治療. 「最新肝癌学」2015

    • Author(s)
      上條岳彦, 檜山英三
    • Total Pages
      8
    • Publisher
      日本臨牀社
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2016-06-03  

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