Mechanism of wound healing process in neurofibromatosis type 1

• Project/Area Number: 26670771
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Osaka University
• Principal Investigator: KUBO TATEKI 大阪大学, 医学(系)研究科(研究院), 准教授 (00362707)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: レックリングハウゼン病 / 神経線維腫症I型 / 線維芽細胞 / 筋線維芽細胞

Outline of Final Research Achievements

It has been known that neurofibromatosis type 1 (NF-1) patients don’t develop hypertrophic scar and keloid. Therefore, if the mechanism of wound healing process in NF-1 is fully understood, it may be applicable for the treatment of hypertrophic scar and keloid. We cultured dermal fibroblasts from NF-1 patients and analyzed the behavior of those cells. Decrease in response to the mechanical stress was detected, possibly due to dysfunction of actin polymerization. Neurofibromin was considered to be involved in those abnormal responses.