|Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|Outline of Final Research Achievements
It has been known that neurofibromatosis type 1 (NF-1) patients don’t develop hypertrophic scar and keloid. Therefore, if the mechanism of wound healing process in NF-1 is fully understood, it may be applicable for the treatment of hypertrophic scar and keloid. We cultured dermal fibroblasts from NF-1 patients and analyzed the behavior of those cells. Decrease in response to the mechanical stress was detected, possibly due to dysfunction of actin polymerization. Neurofibromin was considered to be involved in those abnormal responses.