A Study to Subjugate Bone Cycles using siRNA

• Project/Area Number: 26670773
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Nagasaki University
• Principal Investigator: YANO Hiroki 長崎大学, 病院(医学系), 講師 (60325652)
• Co-Investigator(Kenkyū-buntansha): TANAKA Katsuya 長崎大学, 病院(医学系), 客員研究員 (70722750) ; HIRANO Akiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90208835) ; 樫山 和也 長崎大学, 病院(医学系), 医員 (60723591)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: miRNA / 骨形成 / 骨調整 / G蛋白質 / 顔面骨

Outline of Final Research Achievements

This study is primarily intended to control the bone cycle such as bone formation and resorption with siRNAs. Since miR-142 has related to immune system, we’ve gotten the results that it also contributes to the low-weight molecular G proteins operating cytoskeletal action based on the bioinformatics. Although miR-142 signals could not be found in the murine femur by in situ hybridization, miR-142-3p and miR-142-5p were newfound in immune cells by qPCR after cDNA cloning from miRNA extractions.

Research Products

• [Journal Article] The Prolonged Double Vision Is not Only Caused by Adhesion of Orbital Contents After Blowout Fractures: Important Role of the Orbital Proprioception. (2015)
  • Author(s): Yano Hiroki
  • Journal Title: J Craniofac Surg Volume: 26 Issue: 7 Pages: e680-e681
  • DOI: 10.1097/scs.0000000000002139
  • Peer Reviewed
• [Journal Article] The Cranial Base Fracture after the Caldwell-Luc Operation (2015)
  • Author(s): Iwao Atsuhiko, Nakashima Mitsuko, Yano Hiroki
  • Journal Title: Plast Reconstr Surg Glob Open Volume: 3 Issue: 8 Pages: e483-e483
  • DOI: 10.1097/gox.0000000000000464
  • Peer Reviewed
• [Journal Article] 当科における過去10年間の眼窩底骨折手術 われわれの手術適応 (2014)
  • Author(s): 矢野 浩規, 芳原 聖司, 前場 崇宏, 吉本 浩, 平野 明喜
  • Journal Title: 日本頭蓋顎顔面外科学会誌 Volume: ３０ Pages: 9-15
  • Peer Reviewed
• [Journal Article] 顔面骨骨折の骨固定 (2014)
  • Author(s): 矢野 浩規, 平野 明喜
  • Journal Title: PEPARS Volume: 88 Pages: 32-40
• [Presentation] 眼窩悪性リンパ腫１３例の検討 (2015)
  • Author(s): 矢野浩規、吉本浩、大石正雄，高原英作、馬渡星示、平野明喜
  • Organizer: 第３３回日本頭蓋顎顔面外科学会学術集会
  • Place of Presentation: 宝塚ホテル（兵庫県・宝塚市）
  • Year and Date: 2015-11-12
• [Presentation] Solitary Fibrous Tumor as an Orbit Lesion: Report of Three Cases (2015)
  • Author(s): Hiroki Yano, Katsuya Tanaka, Kazuya Kashiyama, Shizuka Suzuki, Akiyoshi Hirano
  • Organizer: The 16th Congress of ISCFS
  • Place of Presentation: ヒルトン東京ベイ(千葉県・舞浜市)
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] 下直筋障害性眼窩底骨折 (2015)
  • Author(s): 矢野浩規 平野明喜
  • Organizer: 第５８回日本形成外科学会・総会学術集会
  • Place of Presentation: ウェスティン都ホテル京都（京都府・京都市）
  • Year and Date: 2015-04-08
• [Presentation] 眼窩骨折手術におけるピットホールと対応 (2015)
  • Author(s): 矢野浩規
  • Organizer: 第20回日本形成外科手術手技学会
  • Place of Presentation: 鎌倉プリンスホテル(鎌倉市)
  • Year and Date: 2015-02-21
• [Presentation] 当科における頭蓋早期癒合症における頭蓋骨骨延長術の検討 (2014)
  • Author(s): 矢野浩規
  • Organizer: 第32回日本頭蓋顎顔面外科学会学術集会
  • Place of Presentation: 大阪市中央公会堂(大阪市)
  • Year and Date: 2014-11-06 – 2014-11-07
• [Book] 形成外科治療手技全集III 創傷外科 (2015)
  • Author(s): 矢野 浩規、平野 明喜
  • Total Pages: 364
  • Publisher: 克誠堂出版
• [Book] 専門医取得に必要な形成外科手技３６-口頭試問への対策- (2015)
  • Author(s): 矢野 浩規、平野 明喜
  • Total Pages: 326
  • Publisher: 克誠堂出版
• [Book] 形成外科治療手技全書III 創傷外科 (上顎骨骨折・下顎骨骨折) (2015)
  • Author(s): 矢野 浩規, 平野 明喜
  • Total Pages: 364
  • Publisher: 克誠堂出版株式会社