The feasibility of regenerative treatment for alveolar cleft with umbilical cord blood-derived mesenchymal stem cells.

• Project/Area Number: 26670779
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Tokai University
• Principal Investigator: Akamatsu Tadashi 東海大学, 医学部, 准教授 (10276850)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 唇顎口蓋裂 / 出生前診断 / 臍帯血 / 間葉系幹細胞 / 骨芽細胞 / 骨再生 / 間葉型幹細胞 / 免疫不全ラット / 細胞移植 / 単核球細胞 / 骨形成 / SCID mouse

Outline of Final Research Achievements

The objective of this research was to evaluate the feasibility of regenerative treatment for alveolar cleft with umbilical cord blood-derived mesenchymal stem cells.
Recent progress of ultrasound examination has brought prenatal diagnosis of cleft lip and palate, and also brought the opportunity for the umbilical cord blood harvest of the patient. We examined the possibility for osteoblast differentiation of mesenchymal stem cells from cryopreserved human umbilical cord blood and in-vivo osteogenesis in severe immunodeficiency rat.