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Mechanisms of influenza virus mRNA nuclear export

Research Project

Project/Area Number 26670781
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionAkita University

Principal Investigator

Imai Yumiko  秋田大学, 医学(系)研究科(研究院), 教授 (50231163)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインフルエンザウイルス / RNA核外輸送 / インフルエンザ
Outline of Final Research Achievements

NXF1 is previously known as a transporter of host mRNA. Using n vitro RNA gel-shift assay, we found that influenza virus mRNA directly binds to NXF1. In addition, we found that influenza virus mRNA can bind to MC domain of NXF1, although host mRNA binds to RBD, suggesting that binding patterns of influenza virus RNA and host RNA to NXF1 are different. Also, we developed a experimental system that can screen the compounds that can inhibit the interaction of viral mRNA and NXF1 MC domain. This may lead to develop the drugs that can inhibit influenza virus mRNA specific nuclear export.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 3 results,  Invited: 12 results) Book (1 results)

  • [Journal Article] Potential cellular targets for anti-influenza drug development.2016

    • Author(s)
      Imai Y, Sakuma S, Imai H, Kuba K, Fujiwara S.
    • Journal Title

      Cellular immunology and immunotherapies

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virus-host interplay to influenza virus infection.2016

    • Author(s)
      Imai Y, Sakuma S, Imai H, Kuba K, Fujiwara S.
    • Journal Title

      Joirnal of Pharmacoceutical Microbiology

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脂肪酸代謝産物によるインフルエンザウイルス増殖抑制2016

    • Author(s)
      今井由美子
    • Journal Title

      感染・炎症・免疫

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
  • [Journal Article] NTF2-like domain of Tap plays a critical role in cargo mRNA recognition and export.2015

    • Author(s)
      Katahira, J., Dimitrova, L., Imai, Y., Hurt, E.
    • Journal Title

      Nucleic Acids Res.

      Volume: 43 Issue: 3 Pages: 1894-1904

    • DOI

      10.1093/nar/gkv039

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus2015

    • Author(s)
      Imai Y
    • Journal Title

      Biochim Biophys Acta

      Volume: 1851 Issue: 4 Pages: 496-502

    • DOI

      10.1016/j.bbalip.2015.01.006

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] インフルエンザによる急性呼吸不全2015

    • Author(s)
      今井由美子
    • Journal Title

      ER・ICUでの薬の使い方・考え方 ―エキスパートの実践と秘訣に学ぶ-2016-'17 ≪救急・集中治療 27 巻臨時増刊号≫

      Volume: 4 Pages: 134-141

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] インフルエンザ感染におけるウイルス―宿主の核内相互作用2015

    • Author(s)
      今井由美子
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 64 Pages: 594-598

    • Related Report
      2015 Annual Research Report
  • [Presentation] 環境応答とエピジェネティクス:ウイルス感染に対する宿主エピゲノム応答機構2015

    • Author(s)
      今井由美子
    • Organizer
      日本分子生物学会・日本生化学会合同大会BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 感染症治療薬、現状と今後の可能性2015

    • Author(s)
      今井由美子
    • Organizer
      日本学術会議東北地区後援会
    • Place of Presentation
      秋田
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Host-microbe interaction: Dynamic nuclear interaction between influenza virus and its host2015

    • Author(s)
      今井由美子
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dynamic nuclear interactions between influenza virus and its host2015

    • Author(s)
      今井由美子
    • Organizer
      感染症研究グローバルネットワークフォーラム2015
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 宿主核内ネットワークを標的としたインフルエンザ治療薬の可能性2015

    • Author(s)
      今井由美子
    • Organizer
      新薬理学セミナー2015
    • Place of Presentation
      富山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Potential of drug development targeting host signaling pathways2015

    • Author(s)
      今井由美子
    • Organizer
      12th Congress of the World Federation of Society of Intensive and Critical Care Medicine
    • Place of Presentation
      ソウル
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Potential of anti-influenza drug development targeting host nuclear network2015

    • Author(s)
      今井由美子
    • Organizer
      Wu Conference
    • Place of Presentation
      北京
    • Year and Date
      2015-08-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Influenza virus infection triggers histone modifications that link to viral pathogenicity2015

    • Author(s)
      Sakuma T, Higashiya M, Fujiwara S, Imai Y
    • Organizer
      日本薬理学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Dynamic nuclear interactions between influenza virus and its host2015

    • Author(s)
      Yumiko Imai
    • Organizer
      IFRec symposium
    • Place of Presentation
      大阪
    • Year and Date
      2015-02-23 – 2015-02-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Influenza virus infection triggers histone modifications that link to viral pathogenicity2015

    • Author(s)
      Sakuma T, Higashiya M, Fujiwara S, Imai Y
    • Organizer
      4th Negative Strand Virus-Japan
    • Place of Presentation
      沖縄
    • Year and Date
      2015-01-19 – 2015-01-21
    • Related Report
      2014 Research-status Report
  • [Presentation] インフルエンザウイルスの病原性発現を調節する核内ネットワーク2014

    • Author(s)
      今井由美子
    • Organizer
      東北大学医学会講演会
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Lipid metabolic pathways control the pathology of severe influenza virus infection2014

    • Author(s)
      Yumiko Imai
    • Organizer
      The Awaji International Forum on Infection and Immunity
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ウイルス宿主相互作用からみたインフルエンザウイルスの病原性発現機構2014

    • Author(s)
      今井由美子
    • Organizer
      耳鼻咽喉科ニューロサイエンス研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脂肪酸代謝物によるウイルスの病原性発現調節機構2014

    • Author(s)
      今井由美子
    • Organizer
      炎症学会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Pathogenesis of viral lung injury2014

    • Author(s)
      Yumiko Imai
    • Organizer
      The Korean Society for Microbiology and Biotechnology
    • Place of Presentation
      フサン
    • Year and Date
      2014-06-26 – 2014-06-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] インフルエンザウイルス感染に対する宿主エピゲノム応答2014

    • Author(s)
      今井由美子
    • Organizer
      エピジェネティクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-23 – 2014-05-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] Frontiers in Anti-Infective Drug Discovery2016

    • Author(s)
      Yumiko Imai, Toshie Sakuma, Hirotaka Imai, Seiki Fujiwara, Keiji Kuba
    • Publisher
      Bentham Science Publishers
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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