Mechanisms of influenza virus mRNA nuclear export
| Project/Area Number |
26670781
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Akita University |
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Principal Investigator |
Imai Yumiko 秋田大学, 医学(系)研究科(研究院), 教授 (50231163)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インフルエンザウイルス / RNA核外輸送 / インフルエンザ |
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| Outline of Final Research Achievements |
NXF1 is previously known as a transporter of host mRNA. Using n vitro RNA gel-shift assay, we found that influenza virus mRNA directly binds to NXF1. In addition, we found that influenza virus mRNA can bind to MC domain of NXF1, although host mRNA binds to RBD, suggesting that binding patterns of influenza virus RNA and host RNA to NXF1 are different. Also, we developed a experimental system that can screen the compounds that can inhibit the interaction of viral mRNA and NXF1 MC domain. This may lead to develop the drugs that can inhibit influenza virus mRNA specific nuclear export.
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Report
(3 results)
Research Products
(24 results)
