| Project/Area Number |
26670783
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAKAZAWA KOICHI 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (10207756)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | acute lung injury / insulin / blood glucose / ARDS / インスリン / 経気道的薬物投与 / 炎症反応 / 上皮性ナトリウムチャンネル |
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| Outline of Final Research Achievements |
The purpose of the present study is to clarify whether insulin exerts anti-inflammatory effects in acute lung injury under normoglycemia. Lung injury was induced by lung lavage. Mechanically ventilated rabbits were treated with either aerosolized insulin or saline. After 6 hours of treatment, the lungs were excised en bloc, and then we examined IL-8, TLR-4, or ENaCα mRNA expression in BALF cells or lung tissue. Aerosolized insulin failed to ameriorated inflammatory responses under normoglycemia, however, the tissue levels of mRNA expression of ENaCα were maintained by insulin. The results suggest that insulin might contribute to the lung fluid clearance via expression of epithelial sodium channel.
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