| Project/Area Number |
26670788
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
Masahiro Ojima 大阪大学, 医学部附属病院, 医員 (70721091)
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| Co-Investigator(Kenkyū-buntansha) |
吉矢 和久 大阪大学, 医学部附属病院, 助教 (40379201)
山田 知輝 大阪大学, 医学系研究科, 特任研究員 (40623434)
嶋津 岳士 大阪大学, 医学系研究科, 教授 (50196474)
小倉 裕司 大阪大学, 医学系研究科, 准教授 (70301265)
中村 洋平 大阪大学, 医学部附属病院, 医員 (80644004)
新谷 歩 大阪大学, 医学系研究科, 寄附講座教授 (00724395)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腸内細菌叢 / 重症患者 / 高処理シークエンサー / 抗生物質 / 重症度 / シークエンサー / バクテロイデス / ファーミキューティス / OTU |
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| Outline of Final Research Achievements |
It has been shown that the gut microbiota plays an important role in the whole body immune system and it may affect patient's prognosis and infectious complications in emergency patients. In recent years, it has become possible to analyze comprehensive bacterial mirobiota by high-throughput sequencer. This study revealed the dynamic gut microbiota changes in the acute phase of severe emergency patients and that the antibiotics and the severity of the disease had some effect on gut microbiota change. Also, it was revealed that each patient had a unique gut microbiota at the time of arrival and that the gut microbiota shifted especially up to one week after hospitalization, and thereafter it shifted to a new and static state. It was also shown that the deviation of excessive intestinal flora may adversely affect the life prognosis of the host patient.
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