• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy

Research Project

Project/Area Number 26670789
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionKagoshima University

Principal Investigator

ITO Takashi  鹿児島大学, 医歯(薬)学総合研究科, 講師 (20381171)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Ikuro  鹿児島大学, 大学院医歯学総合研究科, 特任教授 (20082282)
Co-Investigator(Renkei-kenkyūsha) MATSUMOTO Masanori  奈良県立医科大学, 教授 (60316081)
HAYAKAWA Masaki  奈良県立医科大学, 助教 (30516729)
NAKAHARA Mayumi  鹿児島大学, 大学院医歯学総合研究科, 特任助教 (90707514)
KAWAHARA Ko-ichi  大阪工業大学, 工学部生命工学科, 特任教授 (10381170)
Research Collaborator NAGASATO Tomoka  藤森工業株式会社
YAMADA Shingo  株式会社シノテスト
Project Period (FY) 2014-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords敗血症 / 血栓症 / ヒストン / 血管内皮細胞 / von Willebrand因子 / トロンボモジュリン / 細胞外ヒストン / 血栓性微小血管障害症
Outline of Final Research Achievements

Extracellular histones stimulated endothelial cells to release von Willebrand factor (VWF). This resulted in massive thrombosis in glomeruli of histone-injected rats. Recombinant thrombomodulin bound to histones and inhibited histone-induced VWF-rich thrombus formation in rats. These findings suggest a novel role of extracellular histones in the pathogenesis of lethal coagulopathy, including thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC).

Report

(2 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] PAMPs and DAMPs as triggers for DIC2014

    • Author(s)
      Ito T
    • Journal Title

      J Intensive Care

      Volume: 2 Issue: 1 Pages: 67-67

    • DOI

      10.1186/s40560-014-0065-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment.2014

    • Author(s)
      Kawano H, Ito T, Yamada S, Hashiguchi T, Maruyama I, Hisatomi T, Nakamura M, Sakamoto T.
    • Journal Title

      Laboratory Investigations

      Volume: 94(5) Issue: 5 Pages: 569-585

    • DOI

      10.1038/labinvest.2014.46

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyaluronan protection of corneal endothelial cells against extracellular histones after phacoemulsification.2014

    • Author(s)
      Kawano H, Sakamoto T, Ito T, Miyata K, Hashiguchi T, Maruyama I.
    • Journal Title

      J Cataract Refract Surg

      Volume: 40 Issue: 11 Pages: 1885-93

    • DOI

      10.1016/j.jcrs.2014.07.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 敗血症性 DIC における ヒストンの net effect2015

    • Author(s)
      伊藤隆史
    • Organizer
      第42回日本集中治療医学会学術集会
    • Place of Presentation
      東京都(ホテル日航東京)
    • Year and Date
      2015-02-09 – 2015-02-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Extracellular histones and HMGB1 in sepsis-associated coagulopathy2014

    • Author(s)
      Ito T
    • Organizer
      HMGB1 workshop in Stockholm
    • Place of Presentation
      Sweden, Stockholm(Royal Park Hotel)
    • Year and Date
      2014-09-30 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] DIC/TMAの新規メディエーター:ヒストン2014

    • Author(s)
      伊藤隆史
    • Organizer
      第36回日本血栓止血学会学術集会 (JSTH・救急医学会ジョイントシンポジウム)
    • Place of Presentation
      大阪府・大阪市(大阪国際交流センター)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
    • Invited

URL: 

Published: 2014-04-04   Modified: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi