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The receptor and inhibitor of Nucleophosmin

Research Project

Project/Area Number 26670793
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionOsaka Institute of Technology

Principal Investigator

Kawahara Ko-ichi  大阪工業大学, 工学部, 教授 (10381170)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Ikuro  鹿児島大学, 大学院医歯学総合研究科, 特任教授 (20082282)
MIURA Naoki  鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
ITO Takashi  鹿児島大学, 大学院医歯学総合研究科, 講師 (20381171)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords外科系臨床医学 / 救急医学 / DAMPs / アラーミン / ヌクレオフォスミン / 受容体 / 敗血症
Outline of Final Research Achievements

Nucleophosmin, which is a nucleoprotein, is major multifunctional protein involved in ribosomal biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Recently, nucleophosmin is released from endotoxin-stimulated macrophages and induces inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin's receptor and inhibitor remain unclear. In this study, we found the a nucleophosmin's receptor.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] “DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC”2016

    • Author(s)
      Liaw P, Ito T, Iba T, Thachil J, Zeerleder S
    • Journal Title

      Blood Rev.

      Volume: 30

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A natural therapeutic approach for the treatment of periodontitis by MK615.2015

    • Author(s)
      Yoko Morimoto-Yamashita, Yoshiko Kawakami, Syoko Tatsuyama, Keiko Miyashita, Makiko Emoto, Kiyoshi Kikuchi, Ko-ichi Kawahara, Masayuki Tokuda
    • Journal Title

      Medical Hypotheses

      Volume: 85 Issue: 5 Pages: 618-621

    • DOI

      10.1016/j.mehy.2015.07.028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GM2 gangliosidosis variant 0 (Sandhoff disease) in a mixed-breed dog.2015

    • Author(s)
      Kohyama, M., Yabuki, A., Kawasaki, Y., Kawaguchi, H., Miura, N., Kitano, Y., Onitsuka, T., Rahmann, MM., Miyoshi, N., Yamato, O.
    • Journal Title

      J Am Anim Hosp Assoc

      Volume: 51

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography2015

    • Author(s)
      Otomaru, K., Fujikawa, T., Saito, Y., Ando, T., Obi, T., Miura, N., Kubota, C.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 9 Pages: 1191-1193

    • DOI

      10.1292/jvms.15-0153

    • NAID

      130005100727

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.2015

    • Author(s)
      Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
    • Journal Title

      EMBO J.

      Volume: 34 Issue: 8 Pages: 1042-55

    • DOI

      10.15252/embj.201489897

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.2015

    • Author(s)
      Tancharoen S, Matsuyama T, Kawahara K, Tanaka K, Lee LJ, Machigashira M, Noguchi K, Ito T, Imamura T, Potempa J, Kikuchi K,Maruyama I.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 2 Pages: e0117775-e0117775

    • DOI

      10.1371/journal.pone.0117775

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] HMGB1 promotes the development of pulmonary arterial hypertension in rats.2014

    • Author(s)
      Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 7 Pages: e102482-e102482

    • DOI

      10.1371/journal.pone.0102482

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田 哲 丸山征郎、川原幸一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
    • Organizer
      西日本生理学会
    • Place of Presentation
      久留米
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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