The receptor and inhibitor of Nucleophosmin

• Project/Area Number: 26670793
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Osaka Institute of Technology
• Principal Investigator: Kawahara Ko-ichi 大阪工業大学, 工学部, 教授 (10381170)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Ikuro 鹿児島大学, 大学院医歯学総合研究科, 特任教授 (20082282) ; MIURA Naoki 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036) ; ITO Takashi 鹿児島大学, 大学院医歯学総合研究科, 講師 (20381171)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 外科系臨床医学 / 救急医学 / DAMPs / アラーミン / ヌクレオフォスミン / 受容体 / 敗血症

Outline of Final Research Achievements

Nucleophosmin, which is a nucleoprotein, is major multifunctional protein involved in ribosomal biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Recently, nucleophosmin is released from endotoxin-stimulated macrophages and induces inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin's receptor and inhibitor remain unclear. In this study, we found the a nucleophosmin's receptor.

Research Products

• [Journal Article] “DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC” (2016)
  • Author(s): Liaw P, Ito T, Iba T, Thachil J, Zeerleder S
  • Journal Title: Blood Rev. Volume: 30
  • Peer Reviewed
• [Journal Article] A natural therapeutic approach for the treatment of periodontitis by MK615 (2015)
  • Author(s): Yoko Morimoto-Yamashita, Yoshiko Kawakami, Syoko Tatsuyama, Keiko Miyashita, Makiko Emoto, Kiyoshi Kikuchi, Ko-ichi Kawahara, Masayuki Tokuda
  • Journal Title: Med Hypotheses. Volume: 85 Pages: 618-621
  • DOI: 10.1016/j.mehy.2015.07.028
  • Peer Reviewed / Open Access
• [Journal Article] GM2 gangliosidosis variant 0 (Sandhoff disease) in a mixed-breed dog. (2015)
  • Author(s): Kohyama, M., Yabuki, A., Kawasaki, Y., Kawaguchi, H., Miura, N., Kitano, Y., Onitsuka, T., Rahmann, MM., Miyoshi, N., Yamato, O.
  • Journal Title: J Am Anim Hosp Assoc Volume: 51
  • Peer Reviewed
• [Journal Article] Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography (2015)
  • Author(s): Otomaru, K., Fujikawa, T., Saito, Y., Ando, T., Obi, T., Miura, N., Kubota, C.
  • Journal Title: J. Vet. Med. Sci. Volume: 77 Issue: 9 Pages: 1191-1193
  • DOI: 10.1292/jvms.15-0153
  • NAID: 130005100727
  • Peer Reviewed / Open Access
• [Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β (2015)
  • Author(s): Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
  • Journal Title: EMBO J Volume: 34 Pages: 1042-1042
  • DOI: 10.15252/embj.201489897
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients. (2015)
  • Author(s): Tancharoen S, Matsuyama T, Kawahara K, Tanaka K, Lee LJ, Machigashira M, Noguchi K, Ito T, Imamura T, Potempa J, Kikuchi K,Maruyama I.
  • Journal Title: PLOS ONE. Volume: 10
  • DOI: 10.1371/journal.pone.0117775
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HMGB1 promotes the development of pulmonary arterial hypertension in rats. (2014)
  • Author(s): Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I.
  • Journal Title: PLoS One Volume: 9
  • DOI: 10.1371/journal.pone.0102482
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明 (2015)
  • Author(s): 大池加恵、勝野涼太、藤本靖真、安田 哲 丸山征郎、川原幸一
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1β放出機構の解明 (2015)
  • Author(s): 大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
  • Organizer: 西日本生理学会
  • Place of Presentation: 久留米
  • Year and Date: 2015-10-09