| Project/Area Number |
26670797
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
AMIZUKA Norio 北海道大学, 歯学研究科(研究院), 教授 (30242431)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | PTH / 骨形成 / 骨細胞 / 骨細胞性骨溶解 / ミニモデリング / 骨リモデリング / リモデリング / 骨芽細胞 / 前骨芽細胞 / 電子顕微鏡 |
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| Outline of Final Research Achievements |
We have attempted to clarify the bipartite biological action of parathyroid hormone (PTH) on bone metabolism, -anabolic effects and osteocytic osteolysis. We have examined PTH-driven anabolic effects in mice at the regimens of high and low frequent administration. As a consequence, the high frequent PTH administration formed many trabeculae, whereas the low frequent administration induced thick trabeculae; the former seemed to be caused by accelerated bone remodeling, while the latter is resulted from both bone remodeling and mini-modeling (a manner of bone formation independent of osteoclastic bone resorption). Unlike the anabolic effect of PTH, enlarged osteocytic lacunae were observed after several hours of PTH administration - osteocytic osteolysis -, and then, calcium phosphates were deposited on walls of the once-enlarged lacunae.
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