• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the molecular mechanisms regulating the speed of tooth development

Research Project

Project/Area Number 26670798
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

Ohazama Atsushi  新潟大学, 医歯学系, 教授 (40266169)

Co-Investigator(Kenkyū-buntansha) MAEDA Takeyasu  新潟大学, 医歯学系, 教授 (40183941)
KAWANO Yoshiro  朝日大学, 歯学部, 講師 (60303129)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯の発生 / 時間軸 / 発生速度
Outline of Final Research Achievements

The purpose of this study was to investigate the molecular mechanisms regulating the speed of tooth development. Developmental stage of odontogenesis (bud, cap and bell stage) had to be subdivided to examine developmental speed. We have successfully subdivided cap stage tooth germs (most critical point in tooth development) using three-dimensional analysis. The data indicate that early cap stage tooth germs change their shape without varying tooth germ volume. This is followed by a significant alteration in morphology, driven by increasing the tooth germ volume. Then, we tried to identify molecules that can be used as markers for each subdivided cap stage. However, the data so far suggest that new organ culture techniques - leading to more precise tooth development - need to be established to allow identification of these molecules.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi