| Project/Area Number |
26670798
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takeyasu 新潟大学, 医歯学系, 教授 (40183941)
KAWANO Yoshiro 朝日大学, 歯学部, 講師 (60303129)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯の発生 / 時間軸 / 発生速度 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the molecular mechanisms regulating the speed of tooth development. Developmental stage of odontogenesis (bud, cap and bell stage) had to be subdivided to examine developmental speed. We have successfully subdivided cap stage tooth germs (most critical point in tooth development) using three-dimensional analysis. The data indicate that early cap stage tooth germs change their shape without varying tooth germ volume. This is followed by a significant alteration in morphology, driven by increasing the tooth germ volume. Then, we tried to identify molecules that can be used as markers for each subdivided cap stage. However, the data so far suggest that new organ culture techniques - leading to more precise tooth development - need to be established to allow identification of these molecules.
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