| Project/Area Number |
26670809
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ASANO SATOSHI 広島大学, 大学院医歯薬保健学研究院, 助教 (30570535)
HARADA KAE 広島大学, 大学院医歯薬保健学研究院, 助教 (60432663)
YAMAWAKI YOSUKE 広島大学, 大学院医歯薬保健学研究院, 助教 (90584061)
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| Research Collaborator |
OUE KANA 広島大学病院, 歯科診療医
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脂肪細胞 / 分化 / 脱分化 / エネルギー代謝 / 脂肪代謝 / 白色脂肪細胞 / 褐色脂肪細胞 / 脂肪分化 / 寒冷刺激 / ベージュ細胞 |
|---|
| Outline of Final Research Achievements |
We produced PLC-related catalytically inactive protein-knockout (Prip-KO) mice. Prip-KO mice showed a lean phenotype. In this study, we examined whether PRIP is involved in adipocyte differentiation and/or dedifferentiation. Adipocyte differentiation was significantly inhibited in Prip-KO mice compared with wild-type mice. However, a feature of adipocyte dedifferentiation was similar between the two genotypes. This study demonstrated that PRIP regulates the process of adipocyte differentiation and hypertrophy. These findings are inspiring a novel therapeutic strategy for obese patients.
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