Molecular and neural mechanisms for detection, modulation and transmission of taste signal for fat preference
Project/Area Number |
26670810
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Kyushu University |
Principal Investigator |
Ninomiya Yuzo 九州大学, 歯学研究科(研究院), 教授 (50076048)
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Co-Investigator(Kenkyū-buntansha) |
Shigemura Noriatsu 九州大学, 大学院歯学研究院, 准教授 (40336079)
Yoshida Ryusuke 九州大学, 大学院歯学研究院, 講師 (60380705)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 味覚 / 脂質味 / 脂肪酸 / 嗜好 / 高脂肪食 / 耽溺性 |
Outline of Final Research Achievements |
The present study investigated molecular and neural mechanisms of detection, modulation and transmission of taste signals for fat preference. The results showed that there exists selective neural pathway for fatty acids in mice, that some of taste fibers best responding to sweet, umami or Ca are also sensitive to fatty acids, and that sweet-suppressive effect by leptin in diet-induced obese mice decreases with increasing circulating leptin which in turn reciprocally increase sweet-enhancing effect by endocannabinoids (eCBs). In another aspect, repeated stimulation with mixture of sugar and fatty acids gradually increase taste responses to the mixture. This enhancement of responses by repeated stimulations was abolished by eCB receptor blockage, suggesting involvement of eCB in the enhancement. Collectively, taste enhancement of sugar by mixing fatty acids may lead to behavioral preference for the mixture, thereby potential facilitation of development of obesity.
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Report
(3 results)
Research Products
(36 results)
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[Presentation] 味覚受容体の機能(塩味と甘味)2016
Author(s)
重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
Organizer
日本薬学会第136回年会
Place of Presentation
神奈川、パシフィコ横浜
Year and Date
2016-03-26
Related Report
Invited
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[Presentation] レプチンによる甘味抑制機構2016
Author(s)
吉田竜介, 重村憲徳, 二ノ宮裕三
Organizer
第93回日本生理学会大会
Place of Presentation
札幌、札幌コンベンションセンター
Year and Date
2016-03-22
Related Report
Invited
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[Presentation] ホルモンによる味覚(塩味・甘味)感受性調節2015
Author(s)
重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
Organizer
第67回日本生物工学会(招待講演)
Place of Presentation
鹿児島、城山観光ホテル
Year and Date
2015-10-26
Related Report
Invited
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