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Molecular and neural mechanisms for detection, modulation and transmission of taste signal for fat preference

Research Project

Project/Area Number 26670810
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionKyushu University

Principal Investigator

Ninomiya Yuzo  九州大学, 歯学研究科(研究院), 教授 (50076048)

Co-Investigator(Kenkyū-buntansha) Shigemura Noriatsu  九州大学, 大学院歯学研究院, 准教授 (40336079)
Yoshida Ryusuke  九州大学, 大学院歯学研究院, 講師 (60380705)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords味覚 / 脂質味 / 脂肪酸 / 嗜好 / 高脂肪食 / 耽溺性
Outline of Final Research Achievements

The present study investigated molecular and neural mechanisms of detection, modulation and transmission of taste signals for fat preference. The results showed that there exists selective neural pathway for fatty acids in mice, that some of taste fibers best responding to sweet, umami or Ca are also sensitive to fatty acids, and that sweet-suppressive effect by leptin in diet-induced obese mice decreases with increasing circulating leptin which in turn reciprocally increase sweet-enhancing effect by endocannabinoids (eCBs). In another aspect, repeated stimulation with mixture of sugar and fatty acids gradually increase taste responses to the mixture. This enhancement of responses by repeated stimulations was abolished by eCB receptor blockage, suggesting involvement of eCB in the enhancement. Collectively, taste enhancement of sugar by mixing fatty acids may lead to behavioral preference for the mixture, thereby potential facilitation of development of obesity.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (36 results)

All 2016 2015 Other

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 5 results) Presentation (23 results) (of which Int'l Joint Research: 2 results,  Invited: 12 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Taste information derived from T1R-expressing taste cells in mice.2016

    • Author(s)
      Yoshida R, Ninomiya Y.
    • Journal Title

      Biochem J

      Volume: 473 Issue: 5 Pages: 525-536

    • DOI

      10.1042/bj20151015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Recent Advances in Molecular Mechanisms of Taste Signaling and Modifying.2016

    • Author(s)
      Shigemura N, Ninomiya Y.
    • Journal Title

      Int Rev Cell Mol Biol.

      Volume: 323 Pages: 71-106

    • DOI

      10.1016/bs.ircmb.2015.12.004

    • ISBN
      9780128048085
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intracellular acidification is required for full activation of the sweet taste receptor by miraculin.2016

    • Author(s)
      Sanematsu K, Kitagawa M, Yoshida R, Nirasawa S, Shigemura N, Ninomiya Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 22807-22807

    • DOI

      10.1038/srep22807

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The function of glucagon-like peptide-1 in the mouse peripheral taste system2016

    • Author(s)
      Takai S, Yoshida R, YasumatsuK, Shigemura N, Ninomiya Y.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 58 Issue: 1 Pages: 10-15

    • DOI

      10.1016/j.job.2015.09.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glucagon like peptide-1 is specifically involved in sweet taste transmission2015

    • Author(s)
      Shingo Takai, Keiko Yasumatsu, Mayuko Inoue Shusuke Iwata, Ryusuke Yoshida, Noriatsu Shigemura, Yuchio Yanagawa, Daniel J. Drucker, Robert F. Margolskee, Yuzo Ninomiya
    • Journal Title

      The FASEB Journal

      Volume: Vol. 29 Issue: 6 Pages: 1-13

    • DOI

      10.1096/fj.14-265355

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice.2015

    • Author(s)
      Niki M, Jyotaki M, Yoshida R, Yasumatsu K, Shigemura N, DiPatrizio NV, Piomelli D, Ninomiya Y.
    • Journal Title

      J Physiol.

      Volume: Feb 25 Issue: 11 Pages: 1-48

    • DOI

      10.1113/jp270295

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High resolution time-intensity recording with synchronized solution delivery system for the human dynamic taste perception.2015

    • Author(s)
      Goto TK, Yeung AW, Suen JL, Fong BS, Ninomiya Y.
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 245 Pages: 147-155

    • DOI

      10.1016/j.jneumeth.2015.02.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds.2015

    • Author(s)
      Yoshida R, Noguchi K, Shigemura N, Jyotaki M, Takahashi I, Margolskee RF, Ninomiya Y.
    • Journal Title

      Diabetes.

      Volume: 64(11) Issue: 11 Pages: 3751-62

    • DOI

      10.2337/db14-1462

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 味覚受容体の機能(塩味と甘味)2016

    • Author(s)
      重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      神奈川、パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] レプチンによる甘味抑制機構2016

    • Author(s)
      吉田竜介, 重村憲徳, 二ノ宮裕三
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌、札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Reflections on taste research for 40 years: Tracing the lineage for the future2016

    • Author(s)
      Ninomiya Y.
    • Organizer
      International Symposium on Chemosensory Signaling from the Oral cavity to the Brain
    • Place of Presentation
      福岡、九州大学
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Oral-Gut-Brain interaction of taste and nutrient sensing.2015

    • Author(s)
      Ninomiya Y.
    • Organizer
      2015 Annual Meeting Program of Korean Basic Dental Science Society Association
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Enhancement of sweet responses by stimulus repetition may be mediated by endocannabinoid system.2015

    • Author(s)
      Iwata S, Yasumatsu Y, Yoshida R, Shigemura N, Ninomiya Y.
    • Organizer
      The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception.
    • Place of Presentation
      福岡、九州大学
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Bitter taste responses of gustducin-expressing taste cells in mice.2015

    • Author(s)
      Yoshida R, Ninomiya Y.
    • Organizer
      The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception.
    • Place of Presentation
      福岡、九州大学
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Expression of renin-angiotensin system (RAS) components in taste organ.2015

    • Author(s)
      Shigemura N, Ninomiya Y.
    • Organizer
      The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception.
    • Place of Presentation
      福岡、九州大学
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホルモンによる味覚(塩味・甘味)感受性調節2015

    • Author(s)
      重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
    • Organizer
      第67回日本生物工学会(招待講演)
    • Place of Presentation
      鹿児島、城山観光ホテル
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Sweet Taste Genetics, Hormones, and Metabolism.2015

    • Author(s)
      Ninomiya Y
    • Organizer
      Annual Scientific meeting of Monell Chemical Senses Center 2015
    • Place of Presentation
      Pennsylvania, USA
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カンナビノイドレセプターを介した自己増幅的な甘味応答の増強とT1R3非依存性甘味受容経路2015

    • Author(s)
      岩田周介, 吉田竜介, 中野啓子, 重村憲徳, 二ノ宮裕三
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜、じゅうろくプラザ
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス鼓索神経における脂肪酸応答単一神経の記録2015

    • Author(s)
      安松啓子, 吉田竜介, 實松敬介, 重村憲徳, 二ノ宮裕三
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜、じゅうろくプラザ
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス味蕾におけるレニン・アンジオテンシン系の機能解析2015

    • Author(s)
      重村憲徳, 二ノ宮裕三
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜、じゅうろくプラザ
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] レプチンによる甘味応答抑制のメカニズム2015

    • Author(s)
      吉田竜介, 重村憲徳, 二ノ宮裕三
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜、じゅうろくプラザ
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] レプチンによる甘味調節機構2015

    • Author(s)
      吉田竜介
    • Organizer
      生理学研究所研究会「生物学的階層構造をまたぐセルセンサー情報伝達に関する戦略的研究開発」
    • Place of Presentation
      岡崎コンファレンスセンター
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 味細胞におけるエンドカンナビノイドを介した甘味応答の自己増幅2015

    • Author(s)
      岩田周介, 吉田竜介, 重村憲徳, 二ノ宮裕三
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟、朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 甘味受容体T1R2/T1R3に対する味覚修飾作用の解析2015

    • Author(s)
      實松敬介, 重村憲徳, 二ノ宮裕三
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟、朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス鼓索神経における脂肪酸に対する単一神経応答の解析2015

    • Author(s)
      安松啓子, 二ノ宮裕三
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟、朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス苦味受容味細胞の応答特性2015

    • Author(s)
      吉田竜介, 二ノ宮裕三
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟、朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 味蕾内レニン-アンジオテンシン系の機能解析2015

    • Author(s)
      重村憲徳, 二ノ宮裕三
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟、朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 岩田周介, 吉田竜介, 重村憲徳, 二ノ宮裕三2015

    • Author(s)
      エンドカンナビノイドによる自己増幅的甘味増強とT1R3-非依存的甘味受容経路の存在
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟、朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 甘味受容体を起点とした口腔脳腸の味情報~内分泌連関と食調節~2015

    • Author(s)
      二ノ宮裕三
    • Organizer
      第13回高付加価値食品開発のためのフォーラム
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] T1r-independent mechanisms may function in taste cell to detect sugars.2015

    • Author(s)
      Ninomiya Y.
    • Organizer
      International Symposium on Neuroscience in Orofacial sensory-motor functions 2015.
    • Place of Presentation
      大阪、大阪大学中之島センター
    • Year and Date
      2015-05-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Roles of oral-brain-gut interaction in detection, transmission and modulation of taste signals and regulation of food intake.2015

    • Author(s)
      Ninomiya Y, Niki M, Jyotaki M, Takai S, Iwata S, Yoshida R, Shigemura N.
    • Organizer
      The 92th annual meeting of the Physiological Society of Japan
    • Place of Presentation
      Kobe
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 医学のあゆみ Vol 256, No.5(GPCR機能の新展開 【感覚】)2016

    • Author(s)
      實松敬介, 二ノ宮裕三
    • Total Pages
      6
    • Publisher
      医歯薬出版
    • Related Report
      2015 Annual Research Report
  • [Book] CHEMOSENSORY TRANSDUCTION: DETECTION OF ODOR, TASTE AND OTHER CHEMOSTIMULI2016

    • Author(s)
      Takai S, Yoshida R, Shigemura N, Ninomiya Y
    • Total Pages
      19
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report
  • [Book] アンチエイジング医学の基礎と臨床改訂3版2015

    • Author(s)
      重村憲徳, 二ノ宮裕三
    • Total Pages
      2
    • Publisher
      メジカルビュー社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 九州大学 大学院 歯学研究院 口腔常態制御学講座 口腔機能解析学分野(口腔生理学)

    • URL

      http://www.dent.kyushu-u.ac.jp/sosiki/a06/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 九州大学 味覚・嗅覚センサ研究開発センター

    • URL

      http://www.rdctos.kyushu-u.ac.jp/

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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