The development of minimally invasive bone regeneration strategy using neural crest-derived cells of hair follicles.

• Project/Area Number: 26670813
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Showa University
• Principal Investigator: Kamijo Ryutaro 昭和大学, 歯学部, 教授 (70233939)
• Co-Investigator(Kenkyū-buntansha): KATAGIRI Takenobu 埼玉医科大学, 医学部, 教授 (80245802)
• Co-Investigator(Renkei-kenkyūsha): OSUMI Noriko 東北大学, 大学院医学系研究科, 教授 (00220343)
• Research Collaborator: ISEKI Sachiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80251544)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経堤由来細胞 / 毛包 / 骨芽細胞 / ミエリンプロテインゼロ / 骨再生 / 神経堤細胞

Outline of Final Research Achievements

Neural crest cells migrate extensively within the embryo as neural crest-derived cells (NCDCs) to reach target sites. Some NCDCs are maintained in an undifferentiated state throughout the life of primate. Therefore, it is considered that NCDCs are a useful cell source for regenerative medicine and stem cell therapy. To analyze the osteoblastic differentiation potential of NC-derived hair follicle cells (NCDFCs) of adult tissues, we utilized an established line of double transgenic mice in which NCDCs express green fluorescent protein throughout their life. NCDCs were observed in the bulge, which contains adult stem cells, and dermal papilla in adult mice. NCDFCs have high proliferative potential and that many proliferative cells expressed the mesenchymal stem cells marker. NCDFCs differentiated into osteoblast-like cells and support osteoclast differentiation. There results indicate that NCDFCs may be an ideal candidate cell source for bone regenerative medicine.

Research Products

• [Journal Article] Cdc42 is crucial for facial and palatal formation during craniofacial development. (2016)
  • Author(s): Oshima-Nakayama M
  • Journal Title: Bone Reports Volume: 5 Pages: 1-6
  • DOI: 10.1016/j.bonr.2016.01.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rho GTPase protein Cdc42 is critical for postnatal cartilage development. (2016)
  • Author(s): Nagahama R, Yamada A, Tanaka J, Aizawa R, Suzuki D, Kassai H, Yamamoto M, Mishima K, Aiba A, Maki K, Kamijo R.
  • Journal Title: Biochem Biophys Res Commun Volume: 470 Issue: 4 Pages: 813-817
  • DOI: 10.1016/j.bbrc.2016.01.111
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bone micro-fragility caused by the mimetic aging processes in α-klotho deficient mice: in situ nanoindentation assessment of dilatational bands (2015)
  • Author(s): Maruyama N., Shibata Y., Mochizuki A., Yamada A., Maki K., Inoue T., Kamijo R., Miyazaki T.
  • Journal Title: Ｂｉｏｍａｔｅｒｉａｌｓ Volume: ４７ Pages: 62-71
  • DOI: 10.1016/j.biomaterials.2015.01.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways (2015)
  • Author(s): Kurosawa T, Yamada A, Takami M, Suzuki D, Saito Y, Hiranuma K, Enomoto T, Morimura N, Yamamoto M, Iijima T, Shirota T, Itabe H, Kamijo R.
  • Journal Title: FEBS Open Bio Volume: 5 Issue: 1 Pages: 303-307
  • DOI: 10.1016/j.fob.2015.04.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhanced in vitro biological activity generated by surface characteristics of anodically oxidized titanium ― the contribution of the oxidation effect. (2015)
  • Author(s): Wurihan, Yamada A, Suzuki D, Shibata Y, Kamijo R, Miyazaki T
  • Journal Title: European Cells & Materials Volume: 29 Pages: 290-312
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of aging with gene expression profiling in mouse submandibular glands. (2015)
  • Author(s): Saito Y
  • Journal Title: Genomics Data Volume: 5 Pages: 115-119
  • DOI: 10.1016/j.gdata.2015.05.012
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Localization and osteoblastic differentiation potential of neural crest-derived cells in oral tissues of adult mice. (2015)
  • Author(s): Ono M
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 464 Issue: 4 Pages: 1209-1214
  • DOI: 10.1016/j.bbrc.2015.07.106
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Bone Response to Static Compressive Stress at Bone-Implant Interface: The Pilot Study of Critical Static Compressive stress. (2015)
  • Author(s): Ikumi N, Suzawa T, Yoshimura K, Kamijo R.
  • Journal Title: Int J Oral Maxillofac Implants Volume: - Issue: 4 Pages: 827-833
  • DOI: 10.11607/jomi.3715
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oxygenated Static Preservation of Donation after Cardiac Death Liver Grafts Improves Hepatocyte Viability and Function. (2015)
  • Author(s): Yu, J., Murakami, M., Aoki, T., Jiang, B., Jin Z, Koizumi, T., Kusano, M., Kamijo, R., Miyamoto, Y., Enami, Y., Watanabe, M., Otsuka, K
  • Journal Title: European Surgical Research Volume: 56 Issue: 1-2 Pages: 1-18
  • DOI: 10.1159/000441058
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Bropirimine inhibits osteoclast differentiation through production of interferon-β. (2015)
  • Author(s): Suzuki H, Mochizuki A, Yoshimura K, Miyamoto Y, Kaneko K, Inoue T, Chikazu D, Takami M, Kamijo R
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 467 Issue: 1 Pages: 146-151
  • DOI: 10.1016/j.bbrc.2015.09.092
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 口腔顎顔面領域に存在する神経堤由来細胞の成体における分布と細胞分化能 ;新しい骨再生療法の提案 (2015)
  • Author(s): 高橋正皓、小野美樹、須澤徹夫、吉田寛、宇山理紗、槇宏太郎、上條竜太郎
  • Journal Title: 口腔組織培養学会誌 Volume: 24 Pages: 1-8
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 骨代謝とH2S・RSSシグナル (2015)
  • Author(s): 宮本洋一、上條竜太郎
  • Journal Title: 細胞工学 Volume: 34 Pages: 379-383
  • Acknowledgement Compliant
• [Journal Article] Microscopic study on resorption of β-tricalcium phosphate materials by osteoclasts. (2015)
  • Author(s): Matsunaga A, Takami M, Irie T, Mishima K, Inagaki K, Kamijo R.
  • Journal Title: Cytotechnology Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In-situ quasi-static and dynamic nanoindentation tests on calcified nodules formed by osteoblasts: Implication of glucocorticoids responsible for osteoblast calcification (2015)
  • Author(s): Miyamoto S., Miyamoto Y., Shibata Y., Yoshimura K., Izumida E., Suzuki H., Miyazaki T., Maki K., Kamijo R.
  • Journal Title: Acta Biomaterialia Volume: １２ Pages: 216-226
  • DOI: 10.1016/j.actbio.2014.10.038
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cdc42 is critical for cartilage development during endochondral ossification. (2015)
  • Author(s): Suzuki W, Yamada A, Aizawa R, Suzuki D, Kassai H, Harada T, Nakayama M, Nagahama R, Maki K, Takeda S, Yamamoto M, Aiba A, Baba K, Kamijo R
  • Journal Title: Endocrinology Volume: 156 Issue: 1 Pages: 314-322
  • DOI: 10.1210/en.2014-1032
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain. (2014)
  • Author(s): Tomohito Akiyama, Yoichi Miyamoto, Kentaro Yoshimura, Atsushi Yamada, Masamichi Takami, Tetsuo Suzawa, Marie Hoshino, Takahisa Imamura, Chie Akiyama, Rika Yasuhara, Kenji Mishima, Toshifumi Maruyama, Chikara Kohda, Kazuo Tanaka, Jan Potempa, Hisataka Yasuda, Kazuyoshi Baba, Ryutaro Kamijo.
  • Journal Title: J.Biol.Chem. Volume: 289 Issue: 22 Pages: 1-35
  • DOI: 10.1074/jbc.m113.520510
  • Peer Reviewed / Open Access
• [Journal Article] Identification of gene expression profile of neural crest-derived cells isolated from submandibular glands of adult mice. (2014)
  • Author(s): Takahashi M, Suzawa T, Yamada A, Yamaguchi T, Mishima K, Osumi N, Maki K, Kamijo R
  • Journal Title: BBRC Volume: 30 Issue: 2 Pages: 1925-1937
  • DOI: 10.1016/j.bbrc.2014.02.130
  • Peer Reviewed
• [Journal Article] Nanomechanical properties and molecular structures of in vitro mineralized tissues on anodically oxidized titanium surfaces. (2014)
  • Author(s): Jang, I-. K., Tanaka, R., Wurihan, Suzuki, D., Shibata Y., Fujisawa, N., Tanimoto, Y., Ogura, K., Kamijo, R., Miyazaki, T.
  • Journal Title: Nanomedicine Volume: 10 Issue: 3 Pages: 629-637
  • DOI: 10.1016/j.nano.2013.09.007
  • Peer Reviewed
• [Journal Article] Synthetic Octacalcium Phosphate Enhanced Reparative Dentin Formation via Induction of Odontoblast Differentiation. (2013)
  • Author(s): X Wang, T Suzawa, T Miyauchi, B Zhao, R Yasuhara, T Anada, N Nakamura, O Suzuki, R Kamijo.
  • Journal Title: J Tissue Eng Regen Med, Volume: in press Issue: 11 Pages: 1310-1320
  • DOI: 10.1002/term.1669
  • Peer Reviewed
• [Presentation] Cdc42 is critical for cartilage development during endochondral ossification at postnatal stage. (2015)
  • Author(s): Nagahama R, Yamada A, Suzuki D, Maki K, kamijo R
  • Organizer: 2015 ASCB Annual Meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Regulation of nephronectin gene expression by 1α, 25-Dyhydroxyvitamin D3. (2015)
  • Author(s): Hiranuma K,Yamada A, Suzuki D, Iijima T, Kamijo R
  • Organizer: 2015 ASCB Annual Meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Missense mutations in parathyroid hormone 1 receptor found in patients having primary failure of tooth eruption cause decreased response to parathyroid hormone. (2015)
  • Author(s): Izumida E, Miyamoto Y, Yamada A, Saito T, Otsu M, Yamaguchi T, Maki K, Kamijo R
  • Organizer: 2015 ASCB Annual Meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Phagocyte-type NADPH oxidase-derived reactive oxygen species is crucial for activation of hyaluronidase and degradation of extracellular matrix in chondrocytes stimulated by interleukin-1β. (2015)
  • Author(s): Funato S, Yasuhara R, Miyamoto Y, Yoshimura K, Mishima K, Baba K, Kamijo R
  • Organizer: 2015 ASCB Annual Meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] 活性型ビタミンD3による細胞外マトリックスタンパク質Nephronectinの発現制御機構の解明． (2015)
  • Author(s): 平沼克洋、山田篤、上條竜太郎、飯島毅彦
  • Organizer: 第62回昭和大学学士会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-28
• [Presentation] Cdc42遺伝子の生後成長期の軟骨形成における機能解析 (2015)
  • Author(s): 長濱諒、山田篤、上條竜太郎、槇宏太郎
  • Organizer: 第62回昭和大学学士会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-28
• [Presentation] 疾患特異的iPS細胞を用いた疾患発症機構の解明． (2015)
  • Author(s): 泉田恵理、宮本洋一、山口徹太郎、山田 篤、大津 真、上條竜太郎、槇 宏太郎
  • Organizer: 第62回昭和大学学士会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-28
• [Presentation] 炎症性軟骨基質減少の分子メカニズムの解明． (2015)
  • Author(s): 船登咲映、安原理佳、宮本洋一、吉村健太郎、美島健二、馬場一美、上條竜太郎
  • Organizer: 第62回昭和大学学士会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-28
• [Presentation] Nephronectinに対する活性型ビタミンD3の発現制御機構の解析 (2015)
  • Author(s): 平沼克洋、山田篤、鈴木大、飯島毅彦、上條竜太郎
  • Organizer: 第52回日本口腔組織培養学会学術大会
  • Place of Presentation: 徳島
  • Year and Date: 2015-11-21
• [Presentation] Cdc42は生後成長期の軟骨形成に重要である． (2015)
  • Author(s): 長濱諒、山田篤、鈴木大、上條竜太郎、槇宏太郎
  • Organizer: 第52回日本口腔組織培養学会学術大会
  • Place of Presentation: 徳島
  • Year and Date: 2015-11-21
• [Presentation] Cdc42 in neural crest derived cells is essential for palatal development. (2015)
  • Author(s): Mutsuko Oshima, Atsushi Yamada, Dai Suzuki, Koutaro Maki, Ryutaro Kamijo
  • Organizer: ANZBMS 25th Annual Scientific Meeting
  • Place of Presentation: Tasmania, Australia
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] Cdc42 is critical for postnatal cartilage development. (2015)
  • Author(s): 長濱諒、山田篤、槇宏太郎、上條竜太郎
  • Organizer: 第63回国際歯科研究学会日本部会総会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-30
• [Presentation] Interleukin-1βinduces activation of hyaluronidase and degradation of extracellular matrix in murine chondrocytes in a phagocyte-type NADPH oxidase-derived reactive oxygen species-dependent manner. (2015)
  • Author(s): Funato S, Yasuhara R, Miyamoto Y, Yoshimura K, Mishima K, Baba K, Kamijo R
  • Organizer: 第63回国際歯科研究学会日本部会総会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-30
• [Presentation] Expression of nephronection is regulated by 1α, 25-Dyhydroxyvitamin D3. (2015)
  • Author(s): 平沼克洋、山田篤、飯島毅彦、上條竜太郎
  • Organizer: 第63回国際歯科研究学会日本部会総会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-30
• [Presentation] 免疫組織学的観点からみた骨巨細胞腫におけるCD11b陽性細胞の意義 (2015)
  • Author(s): 渋谷 勲、高見正道、榎本拓哉、松永朗裕、中村 茂、上條竜太郎
  • Organizer: 第30回 日本整形外科学会基礎学術集会
  • Place of Presentation: 富山
  • Year and Date: 2015-10-22
• [Presentation] 神経堤由来細胞に発現するRhoファミリー低分子量Gタンパク質Cdc42は口蓋形成に必須である． (2015)
  • Author(s): 大島睦子、山田篤、鈴木大、槇宏太郎、上條竜太郎
  • Organizer: 第57回歯科基礎医学会学術大会・総会
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-11
• [Presentation] 骨/インプラント界面の静的圧縮応力に対する骨の反応静的圧縮の限界応力に関する研究 (2015)
  • Author(s): 井汲憲治、須澤徹夫、吉村健太郎、上條竜太郎
  • Organizer: 第57回歯科基礎医学会学術大会・総会
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-11
• [Presentation] 生命科学の視点から見る口腔インプラント：骨代謝研究の立場から (2015)
  • Author(s): 上條竜太郎
  • Organizer: 公益社団法人 日本口腔インプラント学会 関東・甲信越支部
  • Place of Presentation: 東京
  • Year and Date: 2015-08-02
  • Invited
• [Presentation] 低分子量Gタンパク質Cdc42は口蓋形成において重要な遺伝子である． (2015)
  • Author(s): 大島睦子、山田篤、鈴木大、槙宏太郎、上條竜太郎
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-23
• [Presentation] 内因性活性イオウ種はマウス軟骨細胞の増殖と骨の伸長を促進した． (2015)
  • Author(s): 星野真理江，金子児太郎，宮本洋一，近津大地，馬場一美，上條竜太郎
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-23
• [Presentation] 骨巨細胞腫細胞培養系におけるゾレドロン酸とデノスマブの作用機序の相違． (2015)
  • Author(s): 渋谷 勲、高見正道、榎本拓哉、上條竜太郎、豊根知明
  • Organizer: 第48回 日本整形外科学会 骨・軟部腫瘍学術集会
  • Place of Presentation: 高松
  • Year and Date: 2015-07-09
• [Presentation] 8-ニトロ-cGMPはマウス軟骨細胞の増殖と骨の伸長を促進する新規内因性シグナル分子である． (2015)
  • Author(s): 星野真理江、宮本洋一、金子児太郎、赤池孝章、近津大地、馬場一美、上條竜太郎
  • Organizer: 第15回 東京骨関節フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2015-07-04
• [Presentation] Rhoファミリー低分子量Gタンパク質Rac1およびCdc42の骨･軟骨形成における機能解析． (2015)
  • Author(s): 山田篤、鈴木大、上條竜太郎
  • Organizer: 第1回日本骨免疫学会
  • Place of Presentation: 宮古島
  • Year and Date: 2015-06-30
• [Presentation] 軟骨形成における恒常活性型Rac1の機能解析． (2015)
  • Author(s): 鈴木大、Bush J、上條竜太郎、Beier F
  • Organizer: 第1回日本骨免疫学会
  • Place of Presentation: 宮古島
  • Year and Date: 2015-06-30
• [Presentation] 8-ニトロ-cGMPは骨伸長を促進する新規内因性シグナル分子である． (2015)
  • Author(s): 星野真理江、宮本洋一、金子児太郎、赤池孝章、近津大地、馬場一美、上條竜太郎
  • Organizer: 第1回日本骨免疫学会
  • Place of Presentation: 宮古島
  • Year and Date: 2015-06-30
• [Presentation] Cdc42遺伝子の口蓋形成過程における機能解析． (2015)
  • Author(s): 大島睦子、山田篤、槇宏太郎、上條竜太郎
  • Organizer: 第69回日本口腔科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-06-14
• [Presentation] 8-Nitro-guanosine 3’,5’-cyclic monophosphate mediates elongation of the growth plate cartilage in mice. (2014)
  • Author(s): Hoshino M, Miyamoto Y, Kaneko K, Yoshimura K, Suzuki D, Akaike T, Baba K, Kamijo R
  • Organizer: The 2014 ASCB/IFCB Meeting
  • Place of Presentation: Philadelphia, PE, U.S.A.
  • Year and Date: 2014-12-06 – 2014-12-11
• [Presentation] Endogenously produced persulfides enhance bone elongation. (2014)
  • Author(s): Hoshino M, Kaneko K, Miyamoto Y, Yoshimura K, Suzuki D, Akaike T, Chikazu D, Baba K, Kamijo R
  • Organizer: Janapnese Association for Dental Research 62th Annual Meeting
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] 成体マウス顎下線から分離した神経堤由来細胞の解析 (2014)
  • Author(s): 高橋正皓，須澤徹夫，山田 篤，山口徹太郎，槇 宏太郎，上條竜太郎
  • Organizer: 第51回日本口腔組織培養学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-15
• [Presentation] ヒトDown症乳歯歯根膜由来細胞のSDF-1発現解析 (2014)
  • Author(s): 浅川剛吉，宮本洋一，吉村健太郎，長谷川智一，山下一恵，嘉手納未季，馬目瑤子，栗谷未来，上條竜太郎，船津手敬弘
  • Organizer: 第31回 日本障害者歯科学会総会および学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] 破骨細胞制御因子による癌骨転移制御 (2014)
  • Author(s): 上條竜太郎
  • Organizer: 第17回癌と骨病変研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-14
  • Invited
• [Presentation] 骨代謝の分子メカニズム (2014)
  • Author(s): 上條竜太郎
  • Organizer: 腫瘍分子研セミナー
  • Place of Presentation: 東京
  • Year and Date: 2014-11-05
  • Invited
• [Presentation] 永久歯先天欠如の新規原因遺伝子 (2014)
  • Author(s): 山口徹太郎，細道一善，矢野圭介，芳賀秀郷，方山光朱，中脇貴俊，富田大介，中村雅典，上條竜太郎，井ノ上逸朗，槇 宏太郎
  • Organizer: 第73回日本矯正歯科学会大会
  • Place of Presentation: 千葉
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] Cdc42は口蓋形成過程において必須の遺伝子である (2014)
  • Author(s): 中山睦子，山田 篤，佐藤友紀，上條竜太郎，槇 宏太郎
  • Organizer: 第73回日本矯正歯科学会大会
  • Place of Presentation: 千葉
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] 破骨細胞の前駆細胞形成における骨芽細胞と炎症性刺激の役割 (2014)
  • Author(s): 高見正道，榎本拓哉，山本松男，上條竜太郎
  • Organizer: 第56回歯科基礎医学会学術大会・総会 サテライトシンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-25
• [Presentation] 培養破骨細胞によるb-TCP製人工骨補填剤オスフェリオンの吸収 (2014)
  • Author(s): 松永朗裕，高見正道，上條竜太郎，稲垣克記
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] 骨髄、脾臓、血液中に存在する破骨細胞分化能をもつ細胞の解析 (2014)
  • Author(s): 榎本拓哉，高見正道，山本松男，上條竜太郎
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] Cdc42は軟骨形成とそれに続く軟骨内骨化に必須である (2014)
  • Author(s): 鈴木 航，山田 篤，相澤 怜，鈴木 大，竹田 秀，山本松男，上條竜太郎
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] 成体マウス顎下線から分離した神経堤由来細胞の遺伝子発現解析 (2014)
  • Author(s): 高橋正皓，須澤徹夫，山田 篤，槇 宏太郎，上條竜太郎
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] ケトン体は骨芽細胞機能を調節する (2014)
  • Author(s): 齊藤彰大，吉村健太郎，宮本洋一，山本松男，上條竜太郎
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] グルココルチコイド系ステロイドは骨芽細胞によるアパタイト含有石灰化物形成とそのかたさを向上させる (2014)
  • Author(s): 宮本 尚，宮本洋一，吉村健太郎，槇 宏太郎，上條竜太郎
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] 骨巨細胞腫細胞に対するDenosumabの効果 (2014)
  • Author(s): 渋谷 勲，高見正道，松本光史，榎本拓哉，松永朗裕，浦野絵里，上條竜太郎
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] 臨床に必要な骨代謝学の基礎 (2014)
  • Author(s): 上條竜太郎
  • Organizer: 平成26年度昭和大学歯学部歯科矯正学・口腔生化学卒後研修
  • Place of Presentation: 東京
  • Year and Date: 2014-07-24
  • Invited
• [Presentation] 培養破骨細胞によるβ-TCP製人工骨補填材オスフェリンの吸収 (2014)
  • Author(s): 松永朗裕，高見正道，上條竜太郎，稲垣克記
  • Organizer: 第14回東京骨関節フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2014-07-19
• [Presentation] 歯周病原菌の毒素による破骨細胞分化の促進 (2014)
  • Author(s): 秋山智人，安原理佳，宮本洋一，今村隆寿，馬場一美，美島健二，上條竜太郎
  • Organizer: 第14回東京骨関節フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2014-07-19
• [Presentation] Modulation of osteoblast by ketone bodies. (2014)
  • Author(s): Saito A, Yoshimura K, Miyamoto Y, Yamamoto M, Kamijo R
  • Organizer: 92nd General Session & Exhibition of IADR
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] アルジネート印象材から創製したケイ酸セメントのラット培養歯髄細胞に対する影響について (2014)
  • Author(s): 増田宜子，山口暢章，山田嘉重，宮本洋一，上條竜太郎，宮﨑 隆
  • Organizer: 日本歯科保存学会2014年度春期学術大会（第140回）
  • Place of Presentation: 大津
  • Year and Date: 2014-06-19 – 2014-06-20
• [Remarks] 昭和大学歯学部口腔生化学講座
  • URL: http://www10.showa-u.ac.jp/~oralbio/