| Project/Area Number |
26670813
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAGIRI Takenobu 埼玉医科大学, 医学部, 教授 (80245802)
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| Co-Investigator(Renkei-kenkyūsha) |
OSUMI Noriko 東北大学, 大学院医学系研究科, 教授 (00220343)
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| Research Collaborator |
ISEKI Sachiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80251544)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経堤由来細胞 / 毛包 / 骨芽細胞 / ミエリンプロテインゼロ / 骨再生 / 神経堤細胞 |
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| Outline of Final Research Achievements |
Neural crest cells migrate extensively within the embryo as neural crest-derived cells (NCDCs) to reach target sites. Some NCDCs are maintained in an undifferentiated state throughout the life of primate. Therefore, it is considered that NCDCs are a useful cell source for regenerative medicine and stem cell therapy. To analyze the osteoblastic differentiation potential of NC-derived hair follicle cells (NCDFCs) of adult tissues, we utilized an established line of double transgenic mice in which NCDCs express green fluorescent protein throughout their life. NCDCs were observed in the bulge, which contains adult stem cells, and dermal papilla in adult mice. NCDFCs have high proliferative potential and that many proliferative cells expressed the mesenchymal stem cells marker. NCDFCs differentiated into osteoblast-like cells and support osteoclast differentiation. There results indicate that NCDFCs may be an ideal candidate cell source for bone regenerative medicine.
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