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Development of an in vitro model of oral lichen planus by utilizing a characteristic of immune-privilege

Research Project

Project/Area Number 26670817
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNiigata University

Principal Investigator

IZUMI KENJI  新潟大学, 医歯学系, 教授 (80242436)

Co-Investigator(Kenkyū-buntansha) ITO AKIKO  新潟大学, 医歯学総合病院, 講師 (80361898)
AKIBA YOSUKE  新潟大学, 医歯学総合病院, 講師 (70547512)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔扁平苔癬 / 口腔粘膜上皮細胞 / CD8陽性T細胞 / インビトロモデル / 共培養 / 免疫特権 / CD8陽性T細胞
Outline of Final Research Achievements

We detected oral mucosa keratinocytes cultured in a tissue culture dish do not express FasL by immunocytochemistry, FACS and RT-PCR analyses. The pharmacological induction of FasL expression was not successful, either. This resulted in the difficulty in developing an in vitro model of oral lichen planus by utilizing a characteristic of immune-privilege. However, we found that approximately 10% of human T cells expressed FasL. This suggestied it may be possible to analyze the T cell-oral keratinocyte pathophysiological interation in vitro.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 口腔扁平苔癬インビトロモデル開発の試み2015

    • Author(s)
      泉 健次,加藤寛子,原 夕子,齋藤直朗,塩見 晶,金谷 貢,大川成剛
    • Organizer
      平成27年度日本歯科理工学会中部地方会夏季セミナー
    • Place of Presentation
      富士屋 (新潟県新潟市)
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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