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Functional analysis of a novel immune signaling molecule involved in allergic response.

Research Project

Project/Area Number 26670822
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionFukuoka Dental College

Principal Investigator

Tanaka Yoshihiko  福岡歯科大学, 歯学部, 教授 (00398083)

Co-Investigator(Kenkyū-buntansha) NAGAO JUN-ICHI  福岡歯科大学, 口腔歯学部, 講師 (30509047)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords免疫・感染・炎症 / シグナル伝達 / 遺伝子 / 細胞・組織 / アレルギー
Outline of Final Research Achievements

T helper cells especially Th2 cells play a triggering role in the allergic response, including oral allergies. However, the mechanism underlying the differentiation of T helper cells into Th2 cells has not been completely elucidated. Our group has studied various signaling molecules controlling the differentiation of T helper cells. We found a novel signaling molecule, which was expressed specifically in Th2 cells during the differentiation of T helper cells. We investigated the characterization and function of the signaling molecule. The expression of the signaling molecule, as in Th2 cells, was not found in other types of T helper cells. The signaling molecule could have some functions in cytokine production and cell migration in T cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (13 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.2015

    • Author(s)
      Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Yoshinori F.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 8820-8820

    • DOI

      10.1038/ncomms9820

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯周病の病態からみた新しい考え方2015

    • Author(s)
      田中芳彦
    • Journal Title

      感染症

      Volume: 45 Pages: 193-202

    • Related Report
      2015 Annual Research Report
  • [Journal Article] DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.2014

    • Author(s)
      Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, et al.
    • Journal Title

      J. Exp. Med.

      Volume: (In press) Issue: 7 Pages: 1407-1419

    • DOI

      10.1084/jem.20131926

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Functional analysis of a novel immune signaling molecule involved in Th2-mediated allergic response.2015

    • Author(s)
      Hashimoto, M., Nagao, J., Tasaki, S., Narita, Y., Cho, T., Yuasa, K., Tanaka, Y.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology.
    • Place of Presentation
      Sapporo
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規免疫系シグナル分子によるアレルギー制御機構の解明2015

    • Author(s)
      橋本麻利江, 永尾潤一, 田﨑園子, 成田由香, 長 環, 湯浅賢治, 田中芳彦
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 口腔カンジダ症を選択的に標的とする免疫制御機構の解明2015

    • Author(s)
      田﨑園子, 長 環, 永尾潤一, 成田由香, 橋本麻利江, 小島 寛, 田中芳彦
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Candida albicansの新規T細胞分化誘導抗原の探索2015

    • Author(s)
      長 環, 田﨑園子, 永尾潤一, 成田由香, 橋本麻利江, 田中芳彦
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 免疫応答を誘導する歯周病原細菌の菌体成分の探索2015

    • Author(s)
      成田由香, 田﨑園子, 橋本麻利江, 永尾潤一, 長 環, 田中芳彦
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯周病原細菌Porphyromonas gingivalisに対する免疫制御機構の解明2015

    • Author(s)
      永尾潤一, 田﨑園子, 橋本麻利江, 成田由香, 長 環, 田中芳彦
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mild heat stress 下のCandida albicansバイオフィルム形成時に発現する遺伝子群の解析2014

    • Author(s)
      田﨑園子, 長 環, 橋本麻利江, 今吉理恵子, 永尾潤一, 小島 寛, 田中芳彦.
    • Organizer
      第58回日本医真菌学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] プロタミンペプチドの濃度依存的抗真菌活性について2014

    • Author(s)
      橋本麻利江, 長 環, 永尾潤一, 今吉理恵子, 田﨑園子, 田中芳彦, 庵原啓司, 御手洗 誠, 阿部 茂, 羽山和美.
    • Organizer
      第58回日本医真菌学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] アレルギー反応に関連した新しいシグナル分子の同定とその機能解析2014

    • Author(s)
      橋本麻利江, 永尾潤一, 田﨑園子, 今吉理恵子, 長 環, 湯浅賢治, 田中芳彦.
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Mild heat stress 下で発現するCandida albicansの表層抗原探索2014

    • Author(s)
      田﨑園子, 長 環, 橋本麻利江, 今吉理恵子, 永尾潤一, 小島 寛, 田中芳彦.
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 病原真菌Candida glabrataのHsp70タンパク質Sse1の機能解析2014

    • Author(s)
      永尾潤一, 長 環, 今吉理恵子, 橋本麻利江, 田﨑園子, 田中芳彦.
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] サケ由来プロタミン派生ペプチドの抗真菌活性に関する評価2014

    • Author(s)
      長 環, 永尾潤一, 今吉理恵子, 橋本麻利江, 田﨑園子, 田中芳彦.
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 免疫応答を誘導する歯周病原細菌の抗原決定基の探索2014

    • Author(s)
      今吉理恵子, 田﨑園子, 橋本麻利江, 永尾潤一, 長 環, 田中芳彦.
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Book] 口腔微生物学・免疫学 第4版2016

    • Author(s)
      田中芳彦(分担執筆): 川端重忠、小松澤均、大原直也、寺尾豊、浜田茂幸 編集.
    • Total Pages
      7
    • Publisher
      医歯薬出版
    • Related Report
      2015 Annual Research Report
  • [Remarks] 感染生物学 田中芳彦

    • URL

      http://www.fdcnet.ac.jp/col/info/teacher/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 感染生物学 田中芳彦

    • URL

      http://www.fdcnet.ac.jp/col/info/teacher/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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