| Project/Area Number |
26670822
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Fukuoka Dental College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAGAO JUN-ICHI 福岡歯科大学, 口腔歯学部, 講師 (30509047)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 免疫・感染・炎症 / シグナル伝達 / 遺伝子 / 細胞・組織 / アレルギー |
|---|
| Outline of Final Research Achievements |
T helper cells especially Th2 cells play a triggering role in the allergic response, including oral allergies. However, the mechanism underlying the differentiation of T helper cells into Th2 cells has not been completely elucidated. Our group has studied various signaling molecules controlling the differentiation of T helper cells. We found a novel signaling molecule, which was expressed specifically in Th2 cells during the differentiation of T helper cells. We investigated the characterization and function of the signaling molecule. The expression of the signaling molecule, as in Th2 cells, was not found in other types of T helper cells. The signaling molecule could have some functions in cytokine production and cell migration in T cells.
|
