| Project/Area Number |
26670825
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
赤峰 昭文 九州大学, 歯学研究院, 教授 (00117053)
和田 尚久 九州大学, 大学病院, 教授 (60380466)
門野内 聡 九州大学, 歯学研究院, 助教 (30609558)
友清 淳 九州大学, 大学病院, 講師 (20507777)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | カルシウム感知受容体 / 歯髄幹細胞 / 象牙芽細胞分化 / アクリル系レジン / デンチンブリッジ / カルシウム / ストロンチウム / リン酸化ERK / TGF-beta-ig-h3 / ヒト歯髄細胞 / カルシウムチャネル / 歯髄細胞 |
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| Outline of Final Research Achievements |
In this study, we looked at the positive function of the signal through calcium sensing receptor (CaSR) on hard tissue formation. We therefore aimed at developing the direct dental pulp capping material that would not induce pulp tissue necrosis beneath the pulp exposed area, but promote dentin bridge formation when it would be applied to pulp exposed portion. First we have obtained human dental pulp stem cells that showed the multi-differentiation properties and expressed mesenchymal stem cell markers. Next when this cell was treated with calcium, a potent CaSR stimulator, we found that it led to the odontoblastic differentiation. Thus, we produced the hydroxyapatite-containing acrylic resin, and then applied it to the pulp exposed model rat. Consequently, we found that this material could induce dentin bridge formation beneath the application area without triggering the necrosis of pulp tissue
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