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Regeneration therapy of the peri-apical lesions

Research Project

Project/Area Number 26670828
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionTokyo Dental College

Principal Investigator

Inoue Takashi  東京歯科大学, 歯学部, 教授 (20125008)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords根尖病巣 / 再生医療 / 足場 / 歯髄細胞 / 歯髄 / 歯内療法 / 再生 / 創傷治癒
Outline of Final Research Achievements

Firstly, opens a mucous and alviolar bone hole in accord with the volume of apical lesion.Then, hole was cleaning and the sterilization around the root.
Then, the hole was filled with three-dimensional gel.As a result, regeneration of periodontal tissue around the tooth root was expected.
In the 1st year, analyzed the surgical resection apical lesion sample at the hospital to support the hypothesis of this study.In the mean time, formed a cavity to a dog and started an experiment. In the second year, the collagen gel including the pulp cell were filled in the cavity. However, the reproduction of the periodontium was seen only in a part.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (4 results) (of which Open Access: 1 results) Presentation (1 results)

  • [Journal Article] 根尖病巣1890症例から見えること2015

    • Author(s)
      井上 孝
    • Journal Title

      歯界展望

      Volume: 125 Pages: 436-444

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The effect of concentrated growth factor on rat bone marrow cells in vitro and on calvarial bone healing in vivo.2015

    • Author(s)
      Takeda Y., Kokubun K., Matsuzaka K., Inoue T
    • Journal Title

      Int. J Oral Maxillofac Implnats

      Volume: 30 Pages: 1187-1196

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 根尖病巣1590症例から見えること2015

    • Author(s)
      井上 孝
    • Journal Title

      歯界展望

      Volume: 125 Pages: 436-444

    • Related Report
      2014 Research-status Report
  • [Journal Article] Radicular cyst amd granuloma: A clinicopathological study of 1590 cases and a literature review.2014

    • Author(s)
      Sanuki,T.,Matsuzaka,K.,Inoue,K.,Hashimoto,K.,Inoue,T.
    • Journal Title

      Journal of Japanese Society for Evidence and Dental Professional

      Volume: 6 Pages: 44-49

    • Related Report
      2014 Research-status Report
  • [Presentation] 根尖性歯周炎の病態的分析2014

    • Author(s)
      佐貫展丈, 井上健児, 松坂賢一, 井上 孝
    • Organizer
      第295回東京歯科大学学会(例会)
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2014-06-01
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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